دورية أكاديمية
Chromosome-mediated resistance of Yersinia enterocolitica serotype O9 to intracellular killing by mouse peritoneal macrophages
| العنوان: | Chromosome-mediated resistance of Yersinia enterocolitica serotype O9 to intracellular killing by mouse peritoneal macrophages |
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| المؤلفون: | Ruiz-Bravo, Alfonso, Jimenez-Valera, María, Sampedro, Antonio, Moreno, Encarnación |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1994 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Articles |
| الوصف: | The survival of Yersinia enterocolitica serotype 09 within mouse peritoneal macrophages was investigated. To evaluate the role of the virulence plasmid in the resistance to intracellular killing, an isogenic pair of virulent (plasmid-bearing) and avirulent (plasmid-less) 09 strains was used. The virulent strain was able to express plasmid-encoded outer membrane proteins and to colonize the Peyer's patches of orally infected mice. When mice were infected intraperitoneally, both strains were recovered at similar rates and over the same time from the peritoneal cavity. When in vitro assays were performed, both strains showed similar resistance to intracellular killing by monolayers of resident and inflammatory peritoneal macrophages. Previous opsonization of bacteria did not modify their survival within macrophage monolayers. We concluded that serotype O9 strains display a chromosome-mediated resistance to intracellular killing by mouse peritoneal macrophages. Moreover, macrophage resistance does not seem to be of importance for virulence of serotype 09 strains in mice. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://femsim.oxfordjournals.org/cgi/content/short/9/4/317Test; http://dx.doi.org/10.1111/j.1574-695X.1994.tb00367.xTest |
| DOI: | 10.1111/j.1574-695X.1994.tb00367.x |
| الإتاحة: | https://doi.org/10.1111/j.1574-695X.1994.tb00367.xTest http://femsim.oxfordjournals.org/cgi/content/short/9/4/317Test |
| حقوق: | Copyright (C) 1994, Oxford University Press |
| رقم الانضمام: | edsbas.D745E13C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1574-695X.1994.tb00367.x |
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