دورية أكاديمية
Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats : role in functional capacity and mortality
| العنوان: | Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats : role in functional capacity and mortality |
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| المؤلفون: | L. Jorge, B. Rodrigues, K. T. Rosa, C. Malfitano, T. C. Loureiro, A. Medeiros, R. Curi, P. C. Brum, S. Lacchini, K. De Angelis, M. C. Irigoyen, N. Montano |
| المساهمون: | L Jorge, B. Rodrigue, K. T. Rosa, C. Malfitano, T. C. Loureiro, A. Medeiro, R. Curi, P. C. Brum, S. Lacchini, N. Montano, K. De Angeli, M. C. Irigoyen |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2011 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Autonomic function, Blood flow, Cardiac function, Exercise training, Myocardial infarction, Settore MED/09 - Medicina Interna, Settore MED/11 - Malattie dell'Apparato Cardiovascolare |
| الوصف: | Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats. Methods and results Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO(2) max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 +/- 6%) compared with SI (34 +/- 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group. Conclusion Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/20675661; info:eu-repo/semantics/altIdentifier/wos/WOS:000289162300022; volume:32; issue:7; firstpage:904; lastpage:912; journal:EUROPEAN HEART JOURNAL; http://hdl.handle.net/2434/152011Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79953696804 |
| DOI: | 10.1093/eurheartj/ehq244 |
| الإتاحة: | https://doi.org/10.1093/eurheartj/ehq244Test http://hdl.handle.net/2434/152011Test |
| رقم الانضمام: | edsbas.D21B30F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurheartj/ehq244 |
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