Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
| العنوان: | Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial |
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| المؤلفون: | Minju Sim, Woo Young Chun, Hyun Wook Baik, Lina Cha, Sungwoong Jung, Chong Su Kim, Dong-Mi Shin |
| المصدر: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences |
| بيانات النشر: | Oxford University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Aging, medicine.medical_specialty, THE JOURNAL OF GERONTOLOGY: Biological Sciences, Bifidobacterium longum, ved/biology.organism_classification_rank.species, Gut microbiota, Gut flora, Placebo, law.invention, 03 medical and health sciences, Probiotic, AcademicSubjects/MED00280, 0302 clinical medicine, Cognition, Randomized controlled trial, Double-Blind Method, law, Multicenter trial, Internal medicine, medicine, Humans, Cogntive Function and Memory, Aged, Bifidobacterium bifidum, biology, ved/biology, business.industry, Probiotics, Healthy older adults, biology.organism_classification, Gastrointestinal Microbiome, Affect, 030104 developmental biology, Mood, AcademicSubjects/SCI00960, Female, Cognitive function, Independent Living, Geriatrics and Gerontology, business, Mood status, 030217 neurology & neurosurgery, RCT |
| الوصف: | Probiotics have been proposed to ameliorate cognitive impairment and depressive disorder via the gut–brain axis in patients and experimental animal models. However, the beneficial role of probiotics in brain functions of healthy older adults remains unclear. Therefore, a randomized, double-blind, and placebo-controlled multicenter trial was conducted to determine the effects of probiotics on cognition and mood in community-dwelling older adults. Sixty-three healthy elders (≥65 years) consumed either placebo or probiotics containing Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI for 12 weeks. The gut microbiota was analyzed using 16S rRNA sequencing and bioinformatics. Brain functions were measured using the Consortium to Establish a Registry for Alzheimer’s disease, Satisfaction with life scale, stress questionnaire, Geriatric depression scale, and Positive affect and negative affect schedule. Blood brain-derived neurotrophic factor (BDNF) was determined using enzyme-linked immunosorbent assay. Relative abundance of inflammation-causing gut bacteria was significantly reduced at Week 12 in the probiotics group (p < .05). The probiotics group showed greater improvement in mental flexibility test and stress score than the placebo group (p < .05). Contrary to placebo, probiotics significantly increased serum BDNF level (p < .05). Notably, the gut microbes significantly shifted by probiotics (Eubacterium and Clostridiales) showed significant negative correlation with serum BDNF level only in the probiotics group (RS = −0.37, RS = −0.39, p < .05). In conclusion, probiotics promote mental flexibility and alleviate stress in healthy older adults, along with causing changes in gut microbiota. These results provide evidence supporting health-promoting properties of probiotics as a part of healthy diet in the older adults. |
| اللغة: | English |
| تدمد: | 1758-535X 1079-5006 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e45b56bed91083aab3dcd33dfef6d9Test http://europepmc.org/articles/PMC7861012Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....41e45b56bed91083aab3dcd33dfef6d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1758535X 10795006 |
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