Galactose Ingested with a High-Fat Beverage Increases Postprandial Lipemia Compared with Glucose but Not Fructose Ingestion in Healthy Men
| العنوان: | Galactose Ingested with a High-Fat Beverage Increases Postprandial Lipemia Compared with Glucose but Not Fructose Ingestion in Healthy Men |
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| المؤلفون: | Javier T. Gonzalez, Dylan Thompson, Adrian Holliday, Jonathan D Watkins, Aaron Simpson, James A. Betts, Kevin Deighton |
| المصدر: | The Journal of Nutrition |
| بيانات النشر: | Oxford University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, medicine.medical_treatment, Medicine (miscellaneous), Fructose, Beverages, chemistry.chemical_compound, AcademicSubjects/MED00060, Young Adult, Internal medicine, triacylglycerols, medicine, Dietary Carbohydrates, Ingestion, Humans, Sugar, Nutrition and Dietetics, Insulin, digestive, oral, and skin physiology, fat metabolism, Galactose, Metabolism, Carbohydrate, Postprandial Period, Dietary Fats, Lipids, Endocrinology, Postprandial, Glucose, chemistry, sugar, AcademicSubjects/SCI00960, Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions, metabolism |
| الوصف: | Background Fructose ingestion with a high-fat beverage increases postprandial lipemia when compared with glucose. It is unknown whether other sugars, such as galactose, also increase postprandial lipemia. Objectives The objective was to assess whether galactose ingestion within a high-fat beverage increases postprandial lipemia relative to glucose or fructose. Methods Two experiments were conducted, which contrasted different test drinks under otherwise standardized conditions. In Experiment 1, 10 nonobese men (age: 22 ± 1 y; BMI, 23.5 ± 2.2 kg/2) ingested either galactose or glucose (0.75 g supplemented carbohydrate per⋅kilogram body mass) within a high-fat test drink (0.94 g fat per kilogram body mass). In Experiment 2, a separate group of 9 nonobese men (age: 26 ± 6 y; BMI: 23.5 ± 2.6 kg/m2) ingested either galactose or fructose (identical doses as those in Experiment 1) within the same high-fat test drink. Capillary blood was sampled before and at frequent intervals after ingestion of the test drinks for a 300-min period to determine plasma triacylglycerol, glucose, lactate, nonesterified fatty acid, and insulin concentrations. Paired t tests and 2-way, repeated-measures ANOVA were used to compare conditions within each experiment. Results The incremental AUC for triacylglycerol was greater following galactose ingestion compared with glucose (127 ± 59 compared with 80 ± 48 mmol⋅L−1 × 300 min, respectively; P = 0.04) but not compared with fructose (136 ± 74 compared with 133 ± 63 mmol⋅L−1 ×300 min, respectively; P = 0.91). Plasma lactate concentrations also increased to a greater extent with galactose compared with glucose ingestion (time–condition interaction: P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1541-6100 0022-3166 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97586c31c8dedfde96e77a69658dafd9Test http://europepmc.org/articles/PMC7330468Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....97586c31c8dedfde96e77a69658dafd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15416100 00223166 |
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