Vesicular Glutamate and GABA Transporters Sort to Distinct Sets of Vesicles in a Population of Presynaptic Terminals
| العنوان: | Vesicular Glutamate and GABA Transporters Sort to Distinct Sets of Vesicles in a Population of Presynaptic Terminals |
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| المؤلفون: | Jean-Luc Boulland, Jon Storm-Mathisen, Floris G. Wouterlood, Monica Jenstad, Robert H. Edwards, Amber J. Boekel, Farrukh A. Chaudhry |
| المساهمون: | Anatomy and neurosciences, NCA - Neurodegeneration |
| المصدر: | Boulland, J L, Jenstad, M, Boekel, A J, Wouterlood, F G, Edwards, R J, Storm-Mathisen, J & Chaudhry, F A 2009, ' Vesicular Glutamate and GABA Transporters Sort to Distinct Sets of Vesicles in a Population of Presynaptic Terminals ', Cerebral Cortex, vol. 19, no. 1, pp. 241-248 . https://doi.org/10.1093/cercor/bhn077Test Cerebral Cortex, 19(1), 241-248. Oxford University Press |
| بيانات النشر: | Oxford University Press, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Vesicular Glutamate Transport Proteins, Vesicular Inhibitory Amino Acid Transport Proteins, Cognitive Neuroscience, Presynaptic Terminals, Vesicular Glutamate Transport Protein 2, Synaptic vesicle, Hippocampus, Cellular and Molecular Neuroscience, medicine, GABA transporter, Animals, Tissue Distribution, Rats, Wistar, Neurons, biology, Dentate gyrus, Glutamate receptor, Articles, Granule cell, Cell biology, Rats, Somatodendritic compartment, medicine.anatomical_structure, biology.protein, Synaptic Vesicles, Neuroscience |
| الوصف: | Vesicular glutamate transporters (VGLUTs) 1 and 2 are expressed by neurons generally accepted to release glutamate as a neurotransmitter, whereas VGLUT3 appears in populations usually associated with a different classical transmitter. We now demonstrate VGLUT2 as well as the vesicular GABA transporter (VGAT) in a subset of presynaptic terminals in the dentate gyrus of the rat hippocampal formation. The terminals are distributed in a characteristic band overlapping with the outer part of the granule cell layer and the inner zone of the molecular layer. Within the terminals, which make asymmetric as well as symmetric synapses onto the somatodendritic compartment of the dentate granule cells, the 2 transporters localize to distinct populations of synaptic vesicles. Moreover, the axons forming these terminals originate in the supramammillary nucleus (SuM). Our data reconcile previous apparently conflicting reports on the physiology of the dentate afferents from SuM and demonstrate that both glutamate and GABA may be released from a single nerve terminal. |
| اللغة: | English |
| تدمد: | 1047-3211 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732dc0d18be33497e6df2ac60f17866cTest https://europepmc.org/articles/PMC3202896Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....732dc0d18be33497e6df2ac60f17866c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10473211 |
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