دورية أكاديمية
Molecular actions of PPARα in lipid metabolism and inflammation
| العنوان: | Molecular actions of PPARα in lipid metabolism and inflammation |
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| المؤلفون: | Bougarne, N, Weyers, B, Desmet, S, Deckers, J, Ray, D, Staels, B, De Bosscher, K |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2018 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Peroxisome proliferator–activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation PPARα agonists, the fibrates, have however been hampered by drug–drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPARα works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:b1207eca-a7d3-4a5c-a3de-b71c12e3ec4cTest; https://doi.org/10.1210/er.2018-00064Test |
| DOI: | 10.1210/er.2018-00064 |
| الإتاحة: | https://doi.org/10.1210/er.2018-00064Test https://ora.ox.ac.uk/objects/uuid:b1207eca-a7d3-4a5c-a3de-b71c12e3ec4cTest |
| حقوق: | info:eu-repo/semantics/embargoedAccess |
| رقم الانضمام: | edsbas.8C97AB6D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/er.2018-00064 |
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