Therapy-induced senescence: opportunities to improve anti-cancer therapy
| العنوان: | Therapy-induced senescence: opportunities to improve anti-cancer therapy |
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| المؤلفون: | Jeffrey Hildesheim, Mansoor M. Ahmed, François Paris, Ana O'Loghlen, Gabriela Riscuta, Dan Xi, Jörg J. Goronzy, Pataje G. S. Prasanna, Daohong Zhou, Judith Campisi, Scott W. Lowe, Sundar Venkatachalam, Guangrong Zheng, David Gius, Clemens A. Schmitt, Paul B. Romesser, C. Norman Coleman, Ann Richmond, Mohamed E Abazeed, Stephen L. Brown, Sandeep Burma, Laura J. Niedernhofer, Jesús Gil, Alexandros G. Georgakilas, David A. Gewirtz, Stephen J. Kron, Marc S. Mendonca, James L. Kirkland, Norman E. Sharpless, Jan M. van Deursen, Deborah Citrin, Mitchell Steven Anscher |
| المساهمون: | Bernardo, Elizabeth, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), University of Florida [Gainesville] (UF), Mayo Clinic [Rochester], Stanford University, University of Chicago, U.S. Food and Drug Administration (FDA), Buck Institute for Research on Aging, Henry Ford Hospital, University of Minnesota [Twin Cities] (UMN), University of Minnesota System, Queen Mary University of London (QMUL), National Technical University of Athens [Athens] (NTUA), Endothelium Radiobiology and Targeting (CRCINA-ÉQUIPE 14), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), University of Texas Southwestern Medical Center [Dallas], Virginia Commonwealth University (VCU), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Vanderbilt University [Nashville], Memorial Sloane Kettering Cancer Center [New York], Indiana University School of Medicine, Indiana University System, University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth) |
| المصدر: | Journal of the National Cancer Institute, vol 113, iss 10 JNCI: Journal of the National Cancer Institute JNCI: Journal of the National Cancer Institute, 2021, 113 (10), pp.1285-1298. ⟨10.1093/jnci/djab064⟩ JNCI Journal of the National Cancer Institute |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Senescence, Cancer Research, Aging, medicine.medical_treatment, Oncology and Carcinogenesis, Radiation Therapy, [SDV.CAN]Life Sciences [q-bio]/Cancer, |
| الوصف: | Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction of tumor cell senescence is also one of the underlying mechanisms by which cancer therapies exert antitumor activity. However, an increasing body of evidence from preclinical studies demonstrates that radiation and chemotherapy cause accumulation of senescent cells (SnCs) both in tumor and normal tissue. SnCs in tumors can, paradoxically, promote tumor relapse, metastasis, and resistance to therapy, in part, through expression of the senescence-associated secretory phenotype. In addition, SnCs in normal tissue can contribute to certain radiation- and chemotherapy-induced side effects. Because of its multiple roles, cellular senescence could serve as an important target in the fight against cancer. This commentary provides a summary of the discussion at the National Cancer Institute Workshop on Radiation, Senescence, and Cancer (August 10-11, 2020, National Cancer Institute, Bethesda, MD) regarding the current status of senescence research, heterogeneity of therapy-induced senescence, current status of senotherapeutics and molecular biomarkers, a concept of “one-two punch” cancer therapy (consisting of therapeutics to induce tumor cell senescence followed by selective clearance of SnCs), and its integration with personalized adaptive tumor therapy. It also identifies key knowledge gaps and outlines future directions in this emerging field to improve treatment outcomes for cancer patients. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0027-8874 1460-2105 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49139a5c6ea60db755d9f1becff4934aTest http://hdl.handle.net/10044/1/89190Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....49139a5c6ea60db755d9f1becff4934a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00278874 14602105 |
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