Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
| العنوان: | Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris |
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| المؤلفون: | Indira Berrio, Florencia Leonardelli, Soraya E. Morales-López, Laura Theill, José Yesid-Rodriguez, Daiana Macedo, Adriana Marin, Catiana Dudiuk, Soledad Gamarra, Soraya Salcedo, Guillermo Garcia-Effron |
| المساهمون: | Ciencia UDES |
| بيانات النشر: | Oxford University Press, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Time Factors, Anidulafungin, ECHINOCANDINS, Echinocandins, chemistry.chemical_compound, Cachexia syndrome, Caspofungin, Amphotericin B, Pharmacology (medical), Pathogen, Candida, chemistry.chemical_classification, Ear, Candida auris, Killing, Infectious Diseases, AMPHOTERICIN B, Micología, POLYENES, CIENCIAS NATURALES Y EXACTAS, medicine.drug, Microbiology (medical), ANTIFUNGAL AGENTS, Echinocandin, CANDIDA AURIS, 030106 microbiology, Microbial Sensitivity Tests, Polyenes, Microbiology, Ciencias Biológicas, 03 medical and health sciences, KILLING, medicine, Pathogenic, Antifungal agents, KINETICS, Inflammation, Pharmacology, Microbial Viability, Malnutrition, PATHOGENIC ORGANISM, bacterial infections and mycoses, CASPOFUNGIN, ANIDULAFUNGIN, Kinetics, 030104 developmental biology, chemistry, Azole, Organism |
| الوصف: | Digital Background: Candida auris is an emerging MDR pathogen. It shows reduced susceptibility to azole drugs and, in some strains, high amphotericin B MICs have been described. For these reasons, echinocandins were proposed as first-line treatment for C. auris infections. However, information on how echinocandins and amphotericin B act against this species is lacking. Objectives: Our aim was to establish the killing kinetics of anidulafungin, caspofungin and amphotericin B against C. auris by time-kill methodology and to determine if these antifungals behave as fungicidal or fungistatic agents against this species. Methods: The susceptibility of 50 C. auris strains was studied. Nine strains were selected (based on echinocandin MICs) to be further studied. Minimal fungicidal concentrations, in vitro dose-response and time-kill patterns were determined. Results: Echinocandins showed lower MIC values than amphotericin B (geometric mean of 0.12 and 0.94 mg/L, respectively). Anidulafungin and caspofungin showed no fungicidal activity at any concentration (maximum log decreases in cfu/mL between 1.34 and 2.22). On the other hand, amphotericin B showed fungicidal activity, but at high concentrations (≥2.00 mg/L). In addition, the tested polyene was faster than echinocandins at killing 50% of the initial inoculum (0.92 versus >8.00 h, respectively). Conclusions: Amphotericin B was the only agent regarded as fungicidal against C. auris. Moreover, C. auris should be considered tolerant to caspofungin and anidulafungin considering that their MFC:MIC ratios were mostly ≥32 and that after 6 h of incubation the starting inoculum was not reduced in >90%. 1 ed. Ciencias Médicas y de la Salud |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03563a04f3e1713923146e960db18764Test https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkz178/5488498Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....03563a04f3e1713923146e960db18764 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |