Neurodevelopmental Disorders, Glycemic Control, and Diabetic Complications in Type 1 Diabetes: a Nationwide Cohort Study
| العنوان: | Neurodevelopmental Disorders, Glycemic Control, and Diabetic Complications in Type 1 Diabetes: a Nationwide Cohort Study |
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| المؤلفون: | Ralf Kuja-Halkola, Soffia Gudbjörnsdottir, Eva Serlachius, Shengxin Liu, Paul Lichtenstein, Ann-Marie Svensson, Agnieszka Butwicka, Jonas F. Ludvigsson, Henrik Larsson, Magnus Tideman |
| المصدر: | The Journal of Clinical Endocrinology and Metabolism |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Pediatrics, type 1 diabetes, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Comorbidity, Biochemistry, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Neurodevelopmental disorder, Diabetic Nephropathies, 030212 general & internal medicine, Longitudinal Studies, Prospective Studies, Child, education.field_of_study, neurodevelopmental disorders, Autism spectrum disorder, Child, Preschool, nephropathy, Female, AcademicSubjects/MED00250, Cohort study, medicine.medical_specialty, Adolescent, Population, 030209 endocrinology & metabolism, Glycemic Control, Diabetes Complications, 03 medical and health sciences, Internal medicine, mental disorders, retinopathy, medicine, Humans, education, Online Only Articles, Clinical Research Articles, Glycemic, Glycated Hemoglobin, Sweden, Type 1 diabetes, Diabetic Retinopathy, business.industry, Biochemistry (medical), Odds ratio, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Glycated hemoglobin, business, Follow-Up Studies |
| الوصف: | Context Neurodevelopmental disorders are more prevalent in childhood-onset type 1 diabetes than in the general population, and the symptoms may limit the individual’s ability for diabetes management. Objective This study investigated whether comorbid neurodevelopmental disorders are associated with long-term glycemic control and risk of diabetic complications. Methods This population-based cohort study used longitudinally collected data from Swedish registers. We identified 11 326 individuals born during 1973-2013, diagnosed with type 1 diabetes during 1990-2013 (median onset age: 9.6 years). Among them, 764 had a comorbid neurodevelopmental disorder, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and intellectual disability. We used multinomial logistic regression to calculate odds ratios (ORs) of having poor glycemic control (assessed by glycated hemoglobin [HbA1c]) and Cox regression to estimate hazard ratios (HRs) of nephropathy and retinopathy. Results The median follow-up was 7.5 years (interquartile range [IQR] 3.9, 11.2). Having any neurodevelopmental disorder (ORadjusted 1.51 [95% CI 1.13, 2.03]), or ADHD (ORadjusted 2.31 [95% CI 1.54, 3.45]) was associated with poor glycemic control (mean HbA1c > 8.5%). Increased risk of diabetic complications was observed in patients with comorbid neurodevelopmental disorders (HRadjusted 1.72 [95% CI 1.21, 2.44] for nephropathy, HRadjusted 1.18 [95% CI 1.00, 1.40] for retinopathy) and patients with ADHD (HRadjusted 1.90 [95% CI 1.20, 3.00] for nephropathy, HRadjusted 1.33 [95% CI 1.07, 1.66] for retinopathy). Patients with intellectual disability have a particularly higher risk of nephropathy (HRadjusted 2.64 [95% CI 1.30, 5.37]). Conclusion Comorbid neurodevelopmental disorders, primarily ADHD and intellectual disability, were associated with poor glycemic control and a higher risk of diabetic complications in childhood-onset type 1 diabetes. |
| اللغة: | English |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff2dfe39f3b2d478655da098b91caefTest http://europepmc.org/articles/PMC8530713Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3ff2dfe39f3b2d478655da098b91caef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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