دورية أكاديمية
N-Acetyltransferase 2 Polymorphisms, Tobacco Smoking, and Breast Cancer Risk in the Breast and Prostate Cancer Cohort Consortium
| العنوان: | N-Acetyltransferase 2 Polymorphisms, Tobacco Smoking, and Breast Cancer Risk in the Breast and Prostate Cancer Cohort Consortium |
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| المؤلفون: | Cox, David G., Dostal, Lucie, Hunter, David J., Le Marchand, Loïc, Hoover, Robert, Ziegler, Regina G., Thun, Michael J., for the Breast and Prostate Cancer Cohort Consortium, Diver, W. Ryan, Stevens, Victoria L., Amiano, Pilar, Boutron-Rualt, Marie-Christine, Campa, Daniele, van Duijnhoven, Fränzel J. B., Gram, Inger T., Kaaks, Rudolf, Khaw, Kay-Tee, Riboli, Elio, Sund, Malin, Trichopoulos, Demitrios, Tumino, Rosario, Vogel, Ulla, Kraft, Peter, Buring, Julie E., Hankinson, Susan E., Lee, I-Min, Zhang, Shumin M., Lindstrom, Sara, Berg, Christine D., Chanock, Stephen, Isaacs, Claudine, McCarty, Catherine, Haiman, Christopher A., Henderson, Brian E. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2011 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Brief Original Contribution |
| الوصف: | Common polymorphisms in the N -acetyltransferase 2 gene ( NAT2 ) modify the association between cigarette smoking and bladder cancer and have been hypothesized to determine whether active cigarette smoking increases breast cancer risk. The authors sought to replicate the latter hypothesis in a prospective analysis of 6,900 breast cancer cases and 9,903 matched controls drawn from 6 cohorts (1989–2006) in the National Cancer Institute’s Breast and Prostate Cancer Cohort Consortium. Standardized methods were used to genotype the 3 most common polymorphisms that define NAT2 acetylation phenotype (rs1799930, rs1799931, and rs1801280). In unconditional logistic regression analyses, breast cancer risk was higher in women with more than 20 pack-years of active cigarette smoking than in never smokers (odds ratio (OR) = 1.28, 95% confidence interval (CI): 1.17, 1.39), after controlling for established risk factors other than alcohol consumption and physical inactivity. However, associations were similar for the slow (OR = 1.25, 95% CI: 1.11, 1.39) and rapid/intermediate (OR = 1.24, 95% CI: 1.08, 1.42) acetylation phenotypes, with no evidence of interaction ( P = 0.87). These results provide some support for the hypothesis that long-term cigarette smoking may be causally associated with breast cancer risk but underscore the need for caution when interpreting sparse data on gene-environment interactions. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://aje.oxfordjournals.org/cgi/content/short/kwr257v1Test; http://dx.doi.org/10.1093/aje/kwr257Test |
| DOI: | 10.1093/aje/kwr257 |
| الإتاحة: | https://doi.org/10.1093/aje/kwr257Test http://aje.oxfordjournals.org/cgi/content/short/kwr257v1Test |
| حقوق: | Copyright (C) 2011, Oxford University Press |
| رقم الانضمام: | edsbas.EBDD7F38 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/aje/kwr257 |
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