Measurement of the AST to LD Ratio in Parathyroid Tissue Suspension Can Precisely Differentiate a Hyperfunctioning Parathyroid
| العنوان: | Measurement of the AST to LD Ratio in Parathyroid Tissue Suspension Can Precisely Differentiate a Hyperfunctioning Parathyroid |
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| المؤلفون: | Toyone Kikumori, Takahiro Inaishi, Masahiro Shibata, Takahiro Ichikawa, Noriyuki Miyajima, Dai Takeuchi |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 105(8):e2764-e2769 |
| بيانات النشر: | Oxford University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Thyroid Gland, Adipose tissue, Biochemistry, hyperparathyroidism, chemistry.chemical_compound, Endocrinology, Reference Values, Medicine, parathyroid, Prospective Studies, Saline, Aged, 80 and over, Thyroid, Middle Aged, Hyperparathyroidism, Primary, frozen section, Parathyroid Neoplasms, medicine.anatomical_structure, Adipose Tissue, Female, Adult, Parathyroidectomy, medicine.medical_specialty, Urology, Diagnosis, Differential, Diagnostic Techniques, Endocrine, Parathyroid Glands, Suspensions, Internal medicine, Lactate dehydrogenase, Humans, Aspartate Aminotransferases, Aged, Frozen section procedure, Hyperparathyroidism, L-Lactate Dehydrogenase, business.industry, Biochemistry (medical), medicine.disease, tissue suspension, biochemical confirmation, ROC Curve, chemistry, Feasibility Studies, business, Primary hyperparathyroidism |
| الوصف: | Background: Frozen section of excised tissue is used to confirm removal of the etiology of primary hyperparathyroidism in the current era of intraoperative parathyroid hormone measurement and provides safeguards for surgeons. We recently reported that the aspartate aminotransferase (AST)/lactate dehydrogenase (LD) ratio in tissue suspension can accurately distinguish normal parathyroid tissue from other tissues. Therefore, we hypothesized that this ratio may also be applied to distinguish hyperfunctioning parathyroid tissue (HPT) from other tissues. Methods: We prospectively analyzed 22 patients who underwent parathyroidectomy for primary hyperparathyroidism (benign, 21; malignant, 1) from July 2018 to October 2019. In total, 27 specimens were examined. Approximately 1 mm3 of minced HPT as confirmed by frozen sections was suspended in 1 mL of normal saline and AST and LD levels were measured. The AST/LD ratios of other tissues (normal parathyroid tissue, thyroid gland, adipose tissue, and others; n = 94) were obtained from our previous report. Results: The AST/LD ratio of benign HPT was consistently higher than that of other tissues (P ファイル公開日: 2021/08/01 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59438b5e664c9ecef8512a0aac343d4dTest https://nagoya.repo.nii.ac.jp/records/31045Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....59438b5e664c9ecef8512a0aac343d4d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0021972X |
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