Vascular surgery-related organ injury and protective strategies: update and future prospects
| العنوان: | Vascular surgery-related organ injury and protective strategies: update and future prospects |
|---|---|
| المؤلفون: | B. Yang, Daqing Ma, Chen Pac-Soo, Anthony Fung |
| المساهمون: | British Journal of Anaesthesia, Royal College Of Anaesthetists |
| المصدر: | ii43 ii32 |
| بيانات النشر: | Oxford University Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, Free Radicals, Population, Acute Lung Injury, Ischemia, Disease, 030204 cardiovascular system & hematology, vascular surgery, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Postoperative Complications, 030202 anesthesiology, Anesthesiology, medicine, Humans, education, Ischemic Postconditioning, Ischemic Preconditioning, Inflammation, education.field_of_study, Endarterectomy, Carotid, Vascular disease, business.industry, Endovascular Procedures, 1103 Clinical Sciences, Vascular surgery, Acute Kidney Injury, medicine.disease, Anesthesiology and Pain Medicine, Protective Agents, Anesthesia, protective agents, business, surgical injuries, Vascular Surgical Procedures, mechanism of action |
| الوصف: | Whilst there has been a reduction in the prevalence of peripheral vascular disease worldwide, a significant proportion of the world's growing population is still affected by disease of the aorta, carotid, iliac and lower limb arteries. These if left untreated can result in severe morbidity and mortality. However vascular surgery, the main definitive treatment for such conditions, is associated with subsequent injury to vital organs including the kidneys, heart, brain, intestines and lungs, with a consequent increase in both morbidity and mortality. The current thinking is that the underlying mechanism of injury is direct organ ischaemia and ischaemia induced formation of free radicals, cytokine release and mitochondrial failure. Various methods to alleviate such injuries have been investigated including pre- and postconditioning strategies, pharmacological therapies including volatile anaesthetic and alpha 2 adrenoceptor agonist drugs and more recently remote conditioning strategies. Although these interventions have demonstrated some reduction in the biomarkers for organ injury, attempts to translate these benefits into clinical practice have not been successful in terms of morbidity, mortality or length of hospital stay. For this reason, further research is needed in this area to facilitate the translation of the potential interventional benefits from bench to bedside. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84c72b991409d2a4438dbe114a3a27cTest http://hdl.handle.net/10044/1/39662Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d84c72b991409d2a4438dbe114a3a27c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |