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Phenotypic and Functional Characterization of Müller Glia Isolated from Induced Pluripotent Stem Cell‐Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation

التفاصيل البيبلوغرافية
العنوان: Phenotypic and Functional Characterization of Müller Glia Isolated from Induced Pluripotent Stem Cell‐Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation
المؤلفون: Karen Eastlake, Weixin Wang, Hari Jayaram, Celia Murray‐Dunning, Amanda J. F. Carr, Conor M. Ramsden, Anthony Vugler, Katrina Gore, Nadine Clemo, Mark Stewart, Pete Coffey, Peng T. Khaw, G. Astrid Limb
المصدر: Stem Cells Translational Medicine, Vol 8, Iss 8, Pp 775-784 (2019)
بيانات النشر: Oxford University Press, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine (General)
LCC:Cytology
مصطلحات موضوعية: Stem cells, Induced pluripotent stem cell, Müller glia, Glaucoma, Regeneration, Medicine (General), R5-920, Cytology, QH573-671
الوصف: Abstract Glaucoma is one of the leading causes of blindness, and there is an ongoing need for new therapies. Recent studies indicate that cell transplantation using Müller glia may be beneficial, but there is a need for novel sources of cells to provide therapeutic benefit. In this study, we have isolated Müller glia from retinal organoids formed by human induced pluripotent stem cells (hiPSCs) in vitro and have shown their ability to partially restore visual function in rats depleted of retinal ganglion cells by NMDA. Based on the present results, we suggest that Müller glia derived from retinal organoids formed by hiPSC may provide an attractive source of cells for human retinal therapies, to prevent and treat vision loss caused by retinal degenerative conditions. Stem Cells Translational Medicine 2019;8:775&784
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2157-6580
2157-6564
33186286
العلاقة: https://doaj.org/toc/2157-6564Test; https://doaj.org/toc/2157-6580Test
DOI: 10.1002/sctm.18-0263
الوصول الحر: https://doaj.org/article/3318628640d742c6b2a42b2b510967aaTest
رقم الانضمام: edsdoj.3318628640d742c6b2a42b2b510967aa
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21576580
21576564
33186286
DOI:10.1002/sctm.18-0263