Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry
| العنوان: | Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry |
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| المؤلفون: | Eva Tomero, Ivan Castellví, Javier Narváez, Elvira Díez, Mercedes Freire, Ángela Pecondón-Español, Lucía Silva-Fernández, Vicenç Torrente-Segarra, Blanca Hernández-Cruz, José Ángel Hernández-Beriain, Jesús Ibáñez Ruan, Iñigo Rúa-Figueroa, Joan Calvet, Ricardo Blanco-Alonso, Teresa Otón, Alejandro Olivé, Mónica Ibáñez-Barcelo, Anisur Rahman, Mónica Fernández-Castro, J.J. Pérez-Venegas, Francisco Javier López-Longo, Santiago Muñoz-Fernández, Antonio Fernández Nebro, María Esther Ruiz-Lucea, Víctor Quevedo-Vila, José Luis Marenco de la Fuente, Juan José Alegre, Mariano Andrés, Carlos Montilla, Vanessa Balboa-Barreiro, Enrique Raya, Carlos Marras Fernandez-Cid, Gregorio Santos-Soler, Tomás Ramón Vázquez-Rodríguez, Ana Lois-Iglesias, José M. Pego-Reigosa, Marian Gantes-Mora, Loreto Horcada Rubio, Jaime Calvo-Alén, María José Galindo, Esther Uriarte Isacelaya, Manuel Rodríguez-Gómez, Ana Sánchez-Atrio, Jacobo de Uña-Álvarez, Gema Bonilla, C. Erausquin, A. Zea |
| المصدر: | RHEUMATOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| بيانات النشر: | OXFORD UNIV PRESS, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, RELESSER, Time Factors, Cross-sectional study, organ damage, Spanish, Disease cluster, Severity of Illness Index, nnortality, 03 medical and health sciences, 0302 clinical medicine, systemic lupus erythematosus, Rheumatology, Internal medicine, Severity of illness, medicine, Cluster Analysis, Humans, Lupus Erythematosus, Systemic, Pharmacology (medical), Musculoskeletal Diseases, Registries, 030212 general & internal medicine, systemic lupus erythennatosus, 030203 arthritis & rheumatology, Lupus erythematosus, Systemic lupus erythematosus, business.industry, Mortality rate, cohort, Middle Aged, medicine.disease, mortality, organ dannage, Cross-Sectional Studies, Cardiovascular Diseases, Spain, Immunology, Cohort, Female, business, cluster analysis |
| الوصف: | Objectives. To identify patterns (clusters) of damage manifestations within a large cohort of SLE patients and evaluate the potential association of these clusters with a higher risk of mortality. Methods. This is a multicentre, descriptive, cross-sectional study of a cohort of 3656 SLE patients from the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics Damage Index. Using cluster analysis, groups of patients with similar patterns of damage manifestations were identified. Then, overall clusters were compared as well as the subgroup of patients within every cluster with disease duration shorter than 5 years. Results. Three damage clusters were identified. Cluster (80.6% of patients) presented a lower amount of individuals with damage (23.2 vs 10096 in clusters 2 and 3. P < 0.001). Cluster 2 (11.4% of patients) was characterized by musculoskeletal damage in all patients. Cluster 3 0.096 of patients) was the only group with cardiovascular damage, and this was present in all patients. The overall mortality rate of patients in clusters 2 and 3 was higher than that in cluster 1 (P < 0.001 for both comparisons) and in patients with disease duration shorter than 5 years as well. Conclusion. In a large cohort of SLE patients, cardiovascular and musculoskeletal damage manifestations were the two dominant forms of damage to sort patients into clinically meaningful clusters. Both in early and late stages of the disease, there was a significant association of these clusters with an increased risk of mortality. Physicians should pay special attention to the early prevention of damage in these two systems. |
| تدمد: | 1462-0324 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935ca8524090e4dd733983c3aa295971Test https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7178Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....935ca8524090e4dd733983c3aa295971 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14620324 |
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