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The Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance

التفاصيل البيبلوغرافية
العنوان: The Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance
المؤلفون: Hidalgo Figueroa, María, Salazar Couso, Alejandro, Romero López Alberca, Cristina, MacDowell, Karina S., García-Bueno, Borja, Bioque, Miquel, Bernardo, Miquel, Parellada, M., González-Pinto, A., García Portilla, María Paz, Lobo, A., Rodriguez-Jimenez, R., Berrocoso Domínguez, Esther María, Leza, Juan Carlos
المساهمون: Estadística e Investigación Operativa, Psicología
المصدر: International Journal of Neuropsychopharmacology (2022)
بيانات النشر: OXFORD UNIV PRESS
سنة النشر: 2022
المجموعة: RODIN - Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
مصطلحات موضوعية: First-episode psychosis, oxytocin, prolactin, cognition, sexual dimorphism
الوصف: Background Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is of interest to identify cognitive and biological markers that will help improve the diagnosis, treatment, and outcome of such events and to define new therapeutic targets. Here we analyzed the plasma oxytocin and prolactin levels during an FEP, assessing their correlation with clinical and cognitive features. Methods The oxytocin and prolactin in plasma was measured in 120 FEP patients and 106 healthy controls, all of whom were subjected to a clinical and neuropsychological assessment. Most patients were under antipsychotics. Statistical analyses aimed to identify factors associated with the FEP and to search for associations between the variables. This study is preliminary and exploratory because the P-values were not corrected for multiple comparisons. Results FEP patients had less oxytocin, more prolactin, and a poor premorbid IQ, and they performed worse in sustained attention. Male patients with higher prolactin levels experienced more severe psychotic symptoms and required higher doses of antipsychotics. Low oxytocin was associated with poor sustained attention in women, whereas low oxytocin and high prolactin in men correlated with better performance in sustained attention. Conclusion Low oxytocin, high prolactin, and poor premorbid IQ and sustained attention are factors associated with an FEP, representing potential therapeutic targets in these patients. These biological factors and cognitive domains might play an important role during a FEP, which could help us to develop new strategies that improve the outcomes of this disorder and that should perhaps be gender specific.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 1461-1457
1469-5111
العلاقة: info:eu-repo/grantAgreement/MICINN//PI11%2F00325/ES/Determinantes clínicos y neurobiológicos de segundos episodios de esquizofrenia. Estudio longitudinal de primeros episodios psicóticos/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F00766/ES/FACTORES QUE INFLUYEN EN LA FUNCIONALIDAD EN LA COMUNIDAD DE PACIENTES CON PRIMEROS EPISODIOS PSICOTICOS: ESTUDIO LONGITUDINAL DE NEUROCOGNICION, COGNICION SOCIAL Y SINTOMAS CLINICOS (PEP2F)/; info:eu-repo/grantAgreement/Junta de Andalucía//FEDER-UCA18-106933; http://hdl.handle.net/10498/27068Test
DOI: 10.1093/ijnp/pyac023
الإتاحة: https://doi.org/10.1093/ijnp/pyac023Test
http://hdl.handle.net/10498/27068Test
حقوق: Atribución-NoComercial 4.0 Internacional ; http://creativecommons.org/licenses/by-nc/4.0Test/ ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.4A2A5EB3
قاعدة البيانات: BASE
الوصف
تدمد:14611457
14695111
DOI:10.1093/ijnp/pyac023