Mediation of the association between obesity and osteoarthritis by blood pressure, vessel wall stiffness and subclinical atherosclerosis
| العنوان: | Mediation of the association between obesity and osteoarthritis by blood pressure, vessel wall stiffness and subclinical atherosclerosis |
|---|---|
| المؤلفون: | Rob J. van der Geest, Hildo J. Lamb, Frits R. Rosendaal, Margreet Kloppenburg, M. Loef, Renée de Mutsert, Saskia le Cessie |
| المصدر: | Rheumatology, 60(7), 3268-3277. OXFORD UNIV PRESS Rheumatology (Oxford, England) Rheumatology |
| بيانات النشر: | OXFORD UNIV PRESS, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, mediation analyses, medicine.medical_specialty, Hand Joints, Population, Osteoarthritis, Pulse Wave Analysis, Logistic regression, Carotid Intima-Media Thickness, vessel wall stiffness, Vascular Stiffness, Rheumatology, Bone Marrow, Internal medicine, medicine, Humans, Pharmacology (medical), Popliteal Artery, Obesity, cardiovascular diseases, education, Pulse wave velocity, AcademicSubjects/MED00360, OA, Netherlands, education.field_of_study, Mediation Analysis, medicine.diagnostic_test, business.industry, blood pressure, Magnetic resonance imaging, Middle Aged, Osteoarthritis, Knee, Clinical Science, medicine.disease, Magnetic Resonance Imaging, Blood pressure, Effusion, Asymptomatic Diseases, Cardiology, cardiovascular system, Female, atherosclerosis, business |
| الوصف: | Objective We investigated the role of blood pressure, vessel wall stiffness [pulse wave velocity (PWV)] and subclinical atherosclerosis markers [carotid intima-media thickness (cIMT), popliteal vessel wall thickness (pVWT)] as mediators of the association of obesity with OA. Methods We used cross-sectional data from a subset of the population-based NEO study (n = 6334). We classified clinical hand and knee OA by the ACR criteria, and structural knee OA, effusion and bone marrow lesions on MRI (n = 1285). cIMT was assessed with ultrasonography. pVWT was estimated on knee MRI (n = 1285), and PWV by abdominal velocity-encoded MRIs (n = 2580), in subpopulations. Associations between BMI and OA were assessed with logistic regression analyses, adjusted for age, sex and education. Blood pressure, cIMT, pVWT and PWV were added to the model to estimate mediation. Results The population consisted of 55% women, with a mean (s.d.) age of 56(6) years. Clinical hand OA was present in 8%, clinical knee OA in 10%, and structural knee OA in 12% of participants. BMI was positively associated with all OA outcomes. cIMT partially mediated the association of BMI with clinical hand OA [10.6 (6.2; 30.5)%], structural knee OA [3.1 (1.9; 7.3)%] and effusion [10.8 (6.0; 37.6)%]. Diastolic blood pressure [2.1 (1.6; 3.0)%] minimally mediated the association between BMI and clinical knee OA. PWV and pVWT did not mediate the association between BMI and OA. Conclusions cIMT and diastolic blood pressure minimally mediated the association of BMI with OA. This suggests that such mediation is trivial in the middle-aged population. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417e24eae58259172a64b56ce83e4c68Test https://hdl.handle.net/1887/3206724Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....417e24eae58259172a64b56ce83e4c68 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |