Clinical significance of serum human epididymis protein 4 in liver fibrosis
| العنوان: | Clinical significance of serum human epididymis protein 4 in liver fibrosis |
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| المؤلفون: | Hui Chen, Detao Li, Feng-Zeng Li, Juan-Juan Chen, Jinqiu Zhao, Yu-Lei Hou |
| المصدر: | Medicine |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Liver Cirrhosis, Male, medicine.medical_specialty, medicine.disease_cause, Sensitivity and Specificity, Gastroenterology, 03 medical and health sciences, Hepatitis B, Chronic, WAP Four-Disulfide Core Domain Protein 2, 0302 clinical medicine, Fibrosis, Internal medicine, medicine, Renal fibrosis, Humans, Clinical significance, 030212 general & internal medicine, Liver Diseases, Alcoholic, diagnostic efficacy, liver fibrosis, Hepatitis B virus, business.industry, Case-control study, Clinical Trial/Experimental Study, serum human epididymis protein 4, General Medicine, Hepatitis C, Hepatitis C, Chronic, Middle Aged, Hepatitis B, medicine.disease, Epididymis, medicine.anatomical_structure, Case-Control Studies, 030220 oncology & carcinogenesis, Female, business, Biomarkers, Research Article |
| الوصف: | Background: Human epididymis protein 4 (HE4) has been identified as marker for renal fibrosis. Present study aimed to investigate the clinical significance of serum HE4 in liver fibrosis. Methods: Serum from 65 liver fibrosis patients, 68 hepatic patients without fibrosis, and 50 controls was collected respectively. Serum HE4 levels were measured by chemiluminescence immunoassay and compared among the groups. The relationships between serum HE4 levels and the clinical characteristics of liver fibrosis were also analyzed. A receiver operator characteristic curve was plotted to investigate the diagnostic efficacy of serum HE4 for liver fibrosis. Child–Pugh (C–P) score and liver fibrosis score were also evaluated. Data were analyzed by statistical software 13.0. Results: Serum HE4 levels were significantly higher in liver fibrosis than that of controls [105.35 (82.64, 164.18) vs 46.2 (39.9, 58.9) pmol L−1, P = .00] and hepatic patients without liver fibrosis [105.35 (82.64, 164.18) vs 51.00 (44.02, 65.65) pmol L−1, P |
| تدمد: | 1536-5964 0025-7974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399749b5d2794cc7e0f4d4c0e4fa313bTest https://doi.org/10.1097/md.0000000000023428Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....399749b5d2794cc7e0f4d4c0e4fa313b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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