التفاصيل البيبلوغرافية
| العنوان: |
A retrospective comparison of COVID-19 and seasonal influenza mortality and outcomes in the ICUs of a French university hospital |
| المؤلفون: |
de Marignan, Donatien, Vacheron, Charles-Hervé, Ader, Florence, Lecocq, Maxime, Richard, Jean Christophe, Frobert, Emilie, Casalegno, Jean Sebastien, Couray-Targe, Sandrine, Argaud, Laurent, Rimmele, Thomas, Aubrun, Frédéric, Dailler, Frédéric, Fellahi, Jean Luc, Bohe, Julien, Piriou, Vincent, Allaouchiche, Bernard, Friggeri, Arnaud, Wallet, Florent |
| المصدر: |
European Journal of Anaesthesiology ; volume 39, issue 5, page 427-435 ; ISSN 0265-0215 1365-2346 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2022 |
| الوصف: |
BACKGROUND SARS-Cov-2 (COVID-19) has become a major worldwide health concern since its appearance in China at the end of 2019. OBJECTIVE To evaluate the intrinsic mortality and burden of COVID-19 and seasonal influenza pneumonia in ICUs in the city of Lyon, France. DESIGN A retrospective study. SETTING Six ICUs in a single institution in Lyon, France. PATIENTS Consecutive patients admitted to an ICU with SARS-CoV-2 pneumonia from 27 February to 4 April 2020 (COVID-19 group) and seasonal influenza pneumonia from 1 November 2015 to 30 April 2019 (influenza group). A total of 350 patients were included in the COVID-19 group (18 refused to consent) and 325 in the influenza group (one refused to consent). Diagnosis was confirmed by RT-PCR. Follow-up was completed on 1 April 2021. MAIN OUTCOME(S) AND MEASURE(S) Differences in 90-day adjusted-mortality between the COVID-19 and influenza groups were evaluated using a multivariable Cox proportional hazards model. RESULTS COVID-19 patients were younger, mostly men and had a higher median BMI, and comorbidities, including immunosuppressive condition or respiratory history were less frequent. In univariate analysis, no significant differences were observed between the two groups regarding in-ICU mortality, 30, 60 and 90-day mortality. After Cox modelling adjusted on age, sex, BMI, cancer, sepsis-related organ failure assessment (SOFA) score, simplified acute physiology score SAPS II score, chronic obstructive pulmonary disease and myocardial infarction, the probability of death associated with COVID-19 was significantly higher in comparison to seasonal influenza [hazard ratio 1.57, 95% CI (1.14 to 2.17); P = 0.006]. The clinical course and morbidity profile of both groups was markedly different; COVID-19 patients had less severe illness at admission (SAPS II score, 37 [28 to 48] vs. 48 [39 to 61], P < 0.001 and SOFA score, 4 [2 to 8] vs. 8 [5 to 11], P < 0.001), but the disease was more severe considering ICU length of stay, duration of mechanical ventilation, PEEP ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/eja.0000000000001672 |
| DOI: |
10.1097/EJA.0000000000001672 |
| الإتاحة: |
https://doi.org/10.1097/eja.0000000000001672Test |
| رقم الانضمام: |
edsbas.8BEAE300 |
| قاعدة البيانات: |
BASE |
