التفاصيل البيبلوغرافية
| العنوان: |
Pancreatic Cancer ; An Exocrine Tumor with Endocrine Characteristics |
| المؤلفون: |
Zhu, Xinzhe, Xiao, Zhiwen, Liu, He, Zhang, Pin, Deng, Shengming, Ding, Lei, Feng, Jingjing, Luo, Jianfeng, Ni, Quanxing, Luo, Guopei, Yu, Xianjun |
| المصدر: |
Annals of Surgery ; ISSN 0003-4932 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2023 |
| الوصف: |
Objective: To examine the characteristics of pancreatic cancer patients with long-term survival Background: Although pancreatic cancer is a highly lethal malignancy, a minority of patients experience long-term survival. The characteristics of these patients remain largely unidentified. Methods: An indolent subgroup was established using carbohydrate antigen 19-9 (CA19-9), which is the best-validated biomarker for pancreatic cancer. Of 1558 patients, 13.9% were included in the CA19-9-normal (≤ 37 U/mL) subgroup. Results: A normal A19-9 level was an independent variable for overall survival (median survival, 18.1 vs. 9.7 months, hazard ratio = 0.53, P < 0.001). The 5-year survival of patients with stage IV CA19-9-normal cancer was higher than that of patients with stage I-IV CA19-9-high cancer (22.4% vs. 6.8%, P = 0.034). The CA19-9-normal subgroup exhibited reduced levels of circulating glucose ( P < 0.001) and increased expression of insulin ( P < 0.001) compared with the CA19-9-high subgroup. Glucose was a substrate for CA19-9 biosynthesis through the hexosamine biosynthesis pathway. In addition, in pancreatic cancer animal models of diabetes, glucose control decreased CA19-9 levels and improved overall survival. In a clinical trial (NCT05306028) of patients before undergoing major anticancer treatments, glucose control decreased CA19-9 levels in 90.9% of the patients. Conclusions: CA19-9-normal pancreatic cancer is a strikingly indolent subgroup with low glucose and high insulin. Glucose control is a promising therapeutic strategy for pancreatic cancer. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/sla.0000000000006168 |
| DOI: |
10.1097/SLA.0000000000006168 |
| الإتاحة: |
https://doi.org/10.1097/sla.0000000000006168Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.13852880 |
| قاعدة البيانات: |
BASE |
