Clinical Manifestations and Outcomes of Patients with Sarcomatoid Hepatocellular Carcinoma
| العنوان: | Clinical Manifestations and Outcomes of Patients with Sarcomatoid Hepatocellular Carcinoma |
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| المؤلفون: | Jia-Horng Kao, Ding-Shinn Chen, Sih-Han Liao, Po-Chin Liang, Yung-Ming Jeng, Tung-Hung Su, Chien-Hung Chen |
| المصدر: | Hepatology. 69:209-221 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Gastroenterology, Internal medicine, medicine, Carcinoma, Humans, Grading (tumors), Aged, Retrospective Studies, Aged, 80 and over, Sarcomatoid Hepatocellular Carcinoma, Hepatology, Proportional hazards model, business.industry, Liver Neoplasms, Hazard ratio, Retrospective cohort study, Middle Aged, medicine.disease, digestive system diseases, Cancer registry, Hepatocellular carcinoma, Female, business |
| الوصف: | Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer-related deaths worldwide. Sarcomatoid HCC is a rare histological subtype of HCC with largely unclear clinical manifestations and outcomes. We evaluated the clinical manifestations and outcomes of patients with sarcomatoid HCC. We identified 5,047 patients with histologically proven HCC from the Cancer Registry Database (1996-2016) of National Taiwan University Hospital. Among them, 40 patients with sarcomatoid HCC were identified from the pathology database of National Taiwan University Hospital. We included 160 patients with nonsarcomatoid HCC through propensity score matching according to sex, age, and Barcelona Clinic Liver Cancer stage. The majority of these patients with sarcomatoid HCC were men (75%); their median age was 58 years. Only 47.5% of the patients with sarcomatoid HCC presented with typical image patterns of HCC. The pathological grading of sarcomatoid HCC was more advanced compared with that of nonsarcomatoid HCC (42.5% vs. 23.8% in grade III and IV, P < 0.0001). The sarcomatoid group had significantly shorter median recurrence-free (13.3 vs. 84.2 months, log-rank P < 0.0001) and overall (8.3 vs. 69.3 months, log-rank P < 0.0001) survival than did the nonsarcomatoid group. The results of the multivariable Cox proportional hazard model revealed histological sarcomatoid subtype as an independent factor for all-cause mortality (hazard ratio [HR], 6.47; 95% confidence interval [CI], 3.12-13.43; P < 0.0001) and tumor recurrence (HR, 4.08; 95% CI, 1.72-9.66; P = 0.001). Conclusion: Compared with nonsarcomatoid HCC, sarcomatoid HCC was associated with more advanced histological grades and atypical image patterns. Histological sarcomatoid subtype is an independent predictor of tumor recurrence after curative treatment and all-cause mortality in patients with HCC. |
| تدمد: | 1527-3350 0270-9139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52d97fc7ca2a59ee4ea54c3d11ef3f1Test https://doi.org/10.1002/hep.30162Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f52d97fc7ca2a59ee4ea54c3d11ef3f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273350 02709139 |
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