التفاصيل البيبلوغرافية
| العنوان: |
Beta oscillations and urinary voiding in Parkinson disease |
| المؤلفون: |
Roy, Holly A., Aziz, Tipu Z., Fitzgerald, James J., Green, Alexander L. |
| المصدر: |
Neurology ; volume 90, issue 17, page e1530-e1534 ; ISSN 0028-3878 1526-632X |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2018 |
| الوصف: |
Objectives To investigate the role of beta oscillations in urinary voiding and their association with lower urinary tract symptoms in Parkinson disease (PD). Methods We used surgically implanted deep brain stimulation electrodes to record local field potential signals from the subthalamic nucleus (STN) and globus pallidus interna (GPi) of patients with PD during urinary voiding. Five patients with STN electrodes and 5 patients with GPi electrodes were tested. We also explored correlations between beta oscillatory power and urinary symptoms assessed by the International Consultation on Incontinence Lower Urinary Tract Symptoms questionnaire. Results Beta suppression occurred during urinary voiding in the GPi ( p < 0.05) but not the STN. Furthermore, the beta signal in the GPi during voiding correlated significantly with severity of incontinence and urinary frequency ( p < 0.05). Conclusions In this study, we have demonstrated that local field potentials can provide information about the neural control of the bladder. Our findings suggest that the GPi is implicated in the process of urinary voiding and that its mechanism of action is linked to signals in the beta frequency band. Moreover, our correlational analyses show that beta oscillations may be implicated more generally in the pathophysiology of lower urinary tract symptoms in PD. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1212/wnl.0000000000005355 |
| DOI: |
10.1212/WNL.0000000000005355 |
| الإتاحة: |
https://doi.org/10.1212/wnl.0000000000005355Test |
| رقم الانضمام: |
edsbas.CD126D4 |
| قاعدة البيانات: |
BASE |
