Lamina-Associated Polypeptide 2α Loss Impairs Heart Function and Stress Response in Mice
| العنوان: | Lamina-Associated Polypeptide 2α Loss Impairs Heart Function and Stress Response in Mice |
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| المؤلفون: | Roland Foisner, Michael Leschnik, Mato Markovic, Colin L. Stewart, Katarzyna Biadasiewicz, Ivana Gotic, Bernhard J. Haubner, Ursula Kolm, Bernhard Metzler |
| المصدر: | Circulation Research. 106:346-353 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Cardiac function curve, medicine.medical_specialty, Heart development, Physiology, GATA4, Biology, medicine.disease, Endocrinology, Downregulation and upregulation, Fibrosis, Internal medicine, medicine, biology.protein, Cardiology and Cardiovascular Medicine, Dystrophin, Tissue homeostasis, Lamin |
| الوصف: | Rationale : Lamina-associated polypeptide (LAP)2α is a mammalian chromatin-binding protein that interacts with a fraction of A-type lamins in the nuclear interior. Because mutations in lamins and LAP2α lead to cardiac disorders in humans, we hypothesized that these factors may play important roles in heart development and adult tissue homeostasis. Objective : We asked whether the presence of LAP2α was required for normal cardiac function. Methods and Results : To study the molecular mechanisms of the disease, we analyzed heart structure and function in complete and conditional Lap2 α −/− mice as well as Lap2 α −/− /Mdx mutants. Unlike conditional deletion of LAP2α in late embryonic striated muscle, its complete knockout caused systolic dysfunction in young mice, accompanied by sporadic fibrosis in old animals, as well as deregulation of major cardiac transcription factors GATA4 and myocyte enhancer factor 2c. Activation of compensatory pathways, including downregulation of β-adrenergic receptor signaling, resulted in reduced responsiveness of the myocardium to chronic β-adrenergic stimulation and stalled the progression of LAP2α-deficient hearts from hypertrophy toward cardiac failure. Dystrophin deficiency in an Mdx background resulted in a transient rescue of the Lap2 α −/− phenotype. Conclusions : Our data suggest a novel role of LAP2α in the maintenance of cardiac function under normal and stress conditions. |
| تدمد: | 1524-4571 0009-7330 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::2dfaf23eb4325017cae5e241f3323ff3Test https://doi.org/10.1161/circresaha.109.205724Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........2dfaf23eb4325017cae5e241f3323ff3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244571 00097330 |
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