التفاصيل البيبلوغرافية
| العنوان: |
The effects of green cardamom supplementation on blood pressure and endothelium function in type 2 diabetic patients ; A study protocol for a randomized controlled clinical trial |
| المؤلفون: |
Ghazi Zahedi, Shohreh, Koohdani, Fariba, Qorbani, Mostafa, Siassi, Fereydoun, Keshavarz, Ali, Nasli-Esfahani, Ensieh, Aghasi, Mohadeseh, Khoshamal, Hoorieh, Sotoudeh, Gity |
| المساهمون: |
Tehran University of Medical Sciences and Health Services |
| المصدر: |
Medicine ; volume 99, issue 18, page e11005 ; ISSN 0025-7974 1536-5964 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2020 |
| الوصف: |
Introduction: Cardamom possesses antioxidant, anti-inflammation, and blood pressure lowering properties, which might improve endothelial function in type 2 diabetic patients. However, no study has examined the effect of cardamom on diabetic patients. The present study aimed to examine the effects of 10-week green cardamom intake on blood pressure, concentrations of inflammatory and endothelial function biomarkers in type 2 diabetes mellitus patients, and its potential mechanisms. Methods and Analysis Design: Eighty overweight or obese patients with type 2 diabetes mellitus (aged 30–60 years) will be recruited into the trial and will assign to receive either cardamom (3 g/day, 6 capsules) or placebo (rusk powder, 6 capsules) for a period of 10 weeks. Systolic blood pressure and diastolic blood pressure, asymmetric dimethylarginine, and nitric oxide will be measured. Serum inflammatory markers namely interleukin 6, tumor necrosis factor-α, high-sensitivity C-reactive protein, and factors related to endothelial function including intercellular adhesion molecule-1, vascular cell adhesion molecule 1, CD62 antigen-like family member E, and cluster of differentiation 163 will be measured at baseline and at the end of the trial. Sociodemographic, International Physical Activity Questionnaire, and three 24-hour dietary recall questionnaires will be collected for each participant. Ethics and dissemination: The study has been approved by The Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.REC.1395.2700). Each participant will sign a written informed consent at the beginning of the study. At the end of the study, results will be published timely manner. Trial registration number: (http://www.irct.irTest, identifier: IRCT-2016042717254N5) Date of registration: 2016-11-23 |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/md.0000000000011005 |
| DOI: |
10.1097/MD.0000000000011005 |
| الإتاحة: |
https://doi.org/10.1097/md.0000000000011005Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.2A96E91E |
| قاعدة البيانات: |
BASE |
