The Value of Serum Amyloid A Levels in Familial Mediterranean Fever to Identify Occult Inflammation During Asymptomatic Periods
| العنوان: | The Value of Serum Amyloid A Levels in Familial Mediterranean Fever to Identify Occult Inflammation During Asymptomatic Periods |
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| المؤلفون: | Şerife Gül Karadağ, Ayşe Tanatar, Nuray Aktay Ayaz, Mustafa Çakan, Hafize Emine Sönmez |
| المصدر: | JCR: Journal of Clinical Rheumatology. 27:1-4 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Turkey, Familial Mediterranean fever, Inflammation, Blood Sedimentation, Gastroenterology, Asymptomatic, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Rheumatology, Internal medicine, medicine, Humans, Longitudinal Studies, 030212 general & internal medicine, Serum amyloid A, Age of Onset, Child, Correlation of Data, 030203 arthritis & rheumatology, Serum Amyloid A Protein, medicine.diagnostic_test, business.industry, Patient Acuity, Acute-phase protein, Symptom Flare Up, medicine.disease, Tubulin Modulators, Familial Mediterranean Fever, C-Reactive Protein, Erythrocyte sedimentation rate, Asymptomatic Diseases, Cohort, Female, medicine.symptom, Age of onset, Colchicine, business |
| الوصف: | OBJECTIVE The aim of this observational study was to evaluate whether there was any correlation between the acute phase reactants in children with familial Mediterranean fever (FMF) during attack and attack-free periods. METHODS The study was conducted between June 2016 and January 2018. Clinical features and laboratory parameters of children with FMF during attack and attack-free periods were recorded longitudinally. RESULTS The cohort consisted of 168 children with FMF (84 boys, 84 girls). Median values of acute phase reactants during FMF attacks were 433.5 mg/L (34.0-1780.0 mg/L) for serum amyloid A (SAA), 56.7 mg/L (7.6-379.0 mg/L) for C-reactive protein (CRP), and 37.5 mm/h (5-100 mm/h) for erythrocyte sedimentation rate (ESR). Median values for the same tests in attack-free periods were 3.2 mg/L (0.1-25.0 mg/L), 1.7 mg/L (0.1-12.7 mg/L), and 8 mm/h (1-30 mm/h), respectively. Correlation analyses showed that SAA and CRP were highly correlated in FMF attack (r = 0.67, p < 0.01), but no correlation was found between SAA and ESR levels. C-reactive protein was elevated in 13.6%, ESR in 20.8%, and SAA in 28.5% of the patients during attack-free period. Age at onset, sex of the patients, and characteristics of attacks were found to be not associated with elevated SAA in attack-free period. On the other hand, having homozygous exon 10 mutation and having elevated CRP were found to be associated with high SAA in attack-free period. CONCLUSIONS C-reactive protein and SAA correlate well with FMF attacks. Therefore, checking for SAA during a FMF attack is not required. However, SAA seems to be the most sensitive method for demonstrating subclinical inflammation in attack-free period. Thus, checking SAA levels might be a valuable tool in selected FMF patients. |
| تدمد: | 1536-7355 1076-1608 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f4faad4aafeef1cf1dc03ac5f9b1a6Test https://doi.org/10.1097/rhu.0000000000001134Test |
| رقم الانضمام: | edsair.doi.dedup.....58f4faad4aafeef1cf1dc03ac5f9b1a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15367355 10761608 |
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