Hepatitis C virus infection as a risk factor for Parkinson disease
| العنوان: | Hepatitis C virus infection as a risk factor for Parkinson disease |
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| المؤلفون: | Cha Ze Lee, Horng-Huei Liou, Hsin-Hsi Tsai, Ruoh-Fang Yen, Chia-Hung Kao, Chih Hsin Muo |
| المصدر: | Neurology. 86:840-846 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Hepatitis C virus, Taiwan, Comorbidity, medicine.disease_cause, Risk Assessment, Sensitivity and Specificity, Cohort Studies, 03 medical and health sciences, Age Distribution, 0302 clinical medicine, Internal medicine, medicine, Humans, Sex Distribution, Risk factor, Aged, Hepatitis B virus, business.industry, Incidence, Reproducibility of Results, virus diseases, Parkinson Disease, Hepatitis C, Middle Aged, medicine.disease, digestive system diseases, Causality, 030104 developmental biology, Immunology, Cohort, Coinfection, Female, Neurology (clinical), Viral hepatitis, business, 030217 neurology & neurosurgery, Cohort study |
| الوصف: | Objective: To determine whether hepatitis C virus (HCV) infection is a risk factor for developing Parkinson disease (PD). Methods: This nationwide population-based cohort study was based on data obtained from a dataset of the Taiwan National Health Insurance Research Database for the period 2000 to 2010. A total of 49,967 patients with viral hepatitis were included for analysis. Furthermore, 199,868 people without viral hepatitis were included for comparisons. Patients with viral hepatitis were further grouped into 3 cohorts: hepatitis B virus (HBV) infection, HCV infection, and HBV-HCV coinfection. In each cohort, we calculated the incidence of developing PD. A Cox proportional hazards model was applied to estimate the risk of developing PD in terms of hazard ratios (HRs) and 95% confidence intervals (CIs). Results: The crude HRs for developing PD was 0.66 (95% CI = 0.55–0.80) for HBV infection, 2.50 (95% CI = 2.07–3.02) for HCV infection, and 1.28 (95% CI = 0.88–1.85) for HBV-HCV coinfection. The association between HCV and PD remained statistically significant after adjustments for age, sex, and comorbidities (adjusted HR = 1.29, 95% CI = 1.06–1.56). Conclusions: We conducted a large nationwide population-based study and found that patients with HCV exhibit a significantly increased risk of developing PD. |
| تدمد: | 1526-632X 0028-3878 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a649a285e6c7315f0ae13eaa5149c5Test https://doi.org/10.1212/wnl.0000000000002307Test |
| رقم الانضمام: | edsair.doi.dedup.....85a649a285e6c7315f0ae13eaa5149c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
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