The Prevent Ovarian Cancer Program (POCP): Identification of Women at Risk for Ovarian Cancer Using Complementary Recruitment Approaches
| العنوان: | The Prevent Ovarian Cancer Program (POCP): Identification of Women at Risk for Ovarian Cancer Using Complementary Recruitment Approaches |
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| المؤلفون: | Jeanna M. McCuaig, Natalie Stickle, Tracy Stockley, Talin Boghosian, Tong Zhang, Raymond H. Kim, Alexandra Volenik, Rochelle Demsky, Nicole Ricker, Alicia A. Tone, Terri Stuart-McEwan, Patricia Shaw, Sarah E. Ferguson, Taymaa May, Suzanne Kamel-Reid, Carl Virtanen, Amit M. Oza, Marcus Q. Bernardini, Susan Armel, Stephane Laframboise, Tina Romagnuolo |
| المصدر: | Obstetrical & Gynecological Survey. 76:476-478 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Oncology, medicine.medical_specialty, Next of kin, Adolescent, Genetic counseling, Carcinoma, Ovarian Epithelial, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Prospective Studies, First-degree relatives, Aged, Genetic testing, Aged, 80 and over, Ontario, Ovarian Neoplasms, medicine.diagnostic_test, business.industry, Patient Selection, Obstetrics and Gynecology, Mean age, General Medicine, Middle Aged, medicine.disease, Large cohort, Serous fluid, 030104 developmental biology, Direct targeting, 030220 oncology & carcinogenesis, Practice Guidelines as Topic, Ovarian carcinomas, Female, Ovarian cancer, business |
| الوصف: | Up to 20% of high-grade serous ovarian carcinomas (HGSOC) are hereditary; however, historical uptake of genetic testing is low. We used a unique combination of approaches to identify women in Ontario, Canada, with a first-degree relative (FDR) who died from HGSOC without prior genetic testing, and offer them multi-gene panel testing.From May 2015-Sept 2019, genetic counseling and testing was provided to eligible participants. Two recruitment strategies were employed, including self-identification in response to an outreach campaign and direct targeting of FDRs of deceased HGSOC patients treated at our institution. The rate of pathogenic variants (PV) in established/potential ovarian cancer risk genes and the benefits/challenges of each approach were assessed.A total of 564 women enrolled in response to our outreach campaign (n = 473) or direct recruitment (n = 91). Mean age at consent was 52 years and 96% did not meet provincial testing criteria. Genetic results were provided to 528 individuals from 458 families. The rate of PVs in ovarian cancer risk genes was highest when FDRs were diagnosed with HGSOC60 years (9.4% vs. 3.9% ≥ 60y, p = 0.0160). Participants in the outreach vs. direct recruitment cohort had a similar rate of PVs; however, uptake of genetic testing (97% vs. 89%; p = 0.0036) and study completion (95% vs. 87%; p = 0.0062) rates were higher in the former. Eleven participants with pathogenic variants have completed risk-reducing gynecologic surgery, with one stage I HGSOC and two breast cancers identified.Overall PV rates in this large cohort were lower than expected; however, we provide evidence that genetic testing criteria in Ontario should include individuals with a deceased FDR diagnosed with HGSOC60 years of age. |
| تدمد: | 1533-9866 0029-7828 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8ef947586932538b666445f60e171cTest https://doi.org/10.1097/01.ogx.0000771040.25420.aaTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3a8ef947586932538b666445f60e171c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15339866 00297828 |
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