Sirolimus-Eluting Stent Versus Paclitaxel-Eluting Stent for Patients With Long Coronary Artery Disease
| العنوان: | Sirolimus-Eluting Stent Versus Paclitaxel-Eluting Stent for Patients With Long Coronary Artery Disease |
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| المؤلفون: | Si Wan Choi, Hyun-Sook Kim, Seung-Whan Lee, Jae Ki Ko, Jae-Hwan Lee, June Hong Kim, Seung-Jung Park, Nae Hee Lee, Sung Cheol Yun, Jae Hyeong Park, Kook Jin Chun, Duk-Woo Park, Yoon Haeng Cho, Seong Wook Park, Young-Hak Kim, Myeong Ki Hong, Cheol Whan Lee, In Whan Seong |
| المصدر: | Circulation. 114:2148-2153 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Paclitaxel, medicine.medical_treatment, Myocardial Infarction, Coronary Artery Disease, Coronary Angiography, Coronary Restenosis, Coronary artery disease, Lesion, Drug Delivery Systems, Restenosis, Physiology (medical), Internal medicine, medicine, Humans, Prospective cohort study, Aged, Sirolimus, medicine.diagnostic_test, business.industry, Incidence, Stent, Equipment Design, Middle Aged, medicine.disease, Treatment Outcome, Relative risk, Retreatment, Angiography, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, medicine.drug |
| الوصف: | Background— Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. This study compared sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) for long coronary lesions. Methods and Results— The present randomized, multicenter, prospective study compared the use of long (≥32 mm) SES with PES in 500 patients with long (≥25 mm) native coronary lesions. The primary end point of the trial was the rate of binary in-segment restenosis according to follow-up angiography at 6 months. The SES and PES groups had similar baseline characteristics. Lesion length was 33.9±11.6 mm in the SES group and 34.5±12.6 mm in the PES group ( P =0.527). The in-segment binary restenosis rate was significantly lower in the SES group than in the PES group (3.3% versus 14.6%; relative risk 0.23; P P P =0.031). Consequently, SES patients had a lower rate of target-lesion revascularization at 9 months (2.4% versus 7.2%, P =0.012). The incidence of death (0.8% in SES versus 0% in PES, P =0.499) or myocardial infarction (8.8% in SES versus 10.8% in PES, P =0.452) at 9 months of follow-up was not statistically different between the 2 groups. Conclusions— For patients with long native coronary artery disease, SES implantation was associated with a reduced incidence of angiographic restenosis and a reduced need for target-lesion revascularization compared with PES implantation. |
| تدمد: | 1524-4539 0009-7322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed08b139c0cdd85b47b20578499ccf28Test https://doi.org/10.1161/circulationaha.106.666396Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ed08b139c0cdd85b47b20578499ccf28 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244539 00097322 |
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