المؤلفون: Elizabeth G. Baxley, Danielle S. Walsh, Jason Higginson, Suzanne Lazorick, Luan Lawson, Donna Lake, Herbert G. Garrison

المصدر: Academic Medicine

مصطلحات موضوعية: Male, Faculty, Medical, Quality management, 020205 medical informatics, Learning community, media_common.quotation_subject, education, 02 engineering and technology, Population health, Education, 03 medical and health sciences, Patient safety, 0302 clinical medicine, North Carolina, 0202 electrical engineering, electronic engineering, information engineering, Humans, Medicine, Quality (business), 030212 general & internal medicine, Curriculum, media_common, Academic Medical Centers, Medical education, Education, Medical, Population Health, business.industry, Innovation Reports, General Medicine, Middle Aged, Health professions, Quality Improvement, Leadership, Female, Interdisciplinary Communication, Patient Safety, business, Healthcare system

الوصف: Problem Although efforts to integrate health systems science (HSS) topics, such as patient safety, quality improvement (QI), interprofessionalism, and population health, into health professions curricula are increasing, the rate of change has been slow. Approach The Teachers of Quality Academy (TQA), Brody School of Medicine at East Carolina University, was established in January 2014 with the dual goal of preparing faculty to lead frontline clinical transformation while becoming proficient in the pedagogy and curriculum design necessary to prepare students in HSS competencies. The TQA included the completion of the Institute for Healthcare Improvement Open School Basic Certificate in Quality and Safety; participation in six 2-day learning sessions on key HSS topics; completion of a QI project; and participation in three online graduate courses. Outcomes Twenty-seven faculty from four health science programs completed the program. All completed their QI projects. Nineteen (70%) have been formally engaged in the design and delivery of the medical student curriculum in HSS. Early into their training, TQA participants began to apply new knowledge and skills in HSS to the development of educational initiatives beyond the medical student curriculum. Next Steps Important next steps for TQA participants and program planners include further incorporation as faculty advisors and contributors to the full implementation of the longitudinal HSS curriculum; expanded involvement with the Leaders in Innovative Care Scholars student leadership distinction track; continued in-depth evaluation of the impact of TQA participation on patient care, teaching, and role modeling; and the recruitment of the next cohort of TQA participants.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7274d3bc838fcc7815a1fc730fdf36ddTest
https://doi.org/10.1097/acm.0000000000001262Test

المؤلفون: Charles F. Jerabek, Ramon A. Castillo, Scott E. Burns, Stephanie R. Lacey, Mark L. Hudak, Steve V. Collins, Tammy S. Herald, Eric L. Ceithaml, Nicholas D. Poulos, Amy R. Bouchard, Jose A. Ettedgui, Eugene B. Freid, Kevin J. Sullivan, Danielle S. Walsh, Frank Trogolo, Mark S. Bleiweis, Stefanie F. Schrum, Ma Ingyinn

المصدر: A & A Case Reports. 2:126-129

مصطلحات موضوعية: medicine.medical_specialty, Fetus, Atrial septectomy, business.industry, medicine.medical_treatment, Perinatal outcome, General Medicine, Hypoxemia, medicine.anatomical_structure, Great arteries, Internal medicine, Ductus arteriosus, medicine, Cardiology, Extracorporeal membrane oxygenation, Cesarean delivery, medicine.symptom, business

الوصف: Prenatal assessment of a fetus with D-transposition of the great arteries demonstrated an absence of mixing between systemic and pulmonary circulations, and predicted lethal postnatal hypoxemia. A multidisciplinary meeting evaluated therapeutic options. After cesarean delivery, veno-venous extracorporeal membrane oxygenation was instituted in preparation for open atrial septectomy. The infant subsequently underwent an arterial switch procedure. Prenatal delineation of pulmonary and systemic circulations in the fetus with D-transposition of the great arteries influences postnatal management. Multidisciplinary planning enhanced the perinatal outcome.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35530f0ee33c86b3d73bacf6af6932eTest
https://doi.org/10.1213/xaa.0000000000000022Test

المؤلفون: S. Houlton, S. Walsh, C. Bowe

المصدر: International Journal of Surgery. 47:S6-S7

مصطلحات موضوعية: medicine.medical_specialty, Cutaneous squamous cell carcinoma, business.industry, General surgery, Medicine, Cancer, Surgery, General Medicine, business, medicine.disease, Head and neck

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::70a21bca6a335590dd5c87d43bc79703Test
https://doi.org/10.1016/j.ijsu.2017.08.055Test

المؤلفون: Zsolt B. Argenyi, Sarah R Hughes, John S. Walsh, Jonathan Bass, Paul S. Furmanczyk, Joe R McFarlane

المصدر: The American Journal of Dermatopathology. 30:600-603

مصطلحات موضوعية: Adult, Male, Seborrheic keratosis, Pathology, medicine.medical_specialty, Skin Neoplasms, Keratosis, Hyperkeratosis, Dermatology, S100 protein, Pathology and Forensic Medicine, medicine, Humans, Ganglioneuroma, Cell Proliferation, Aged, 80 and over, Ganglion Cysts, Cutaneous Ganglioneuroma, business.industry, S100 Proteins, General Medicine, Anatomy, medicine.disease, Ganglion, medicine.anatomical_structure, Phosphopyruvate Hydratase, Immunohistochemistry, Female, Schwann Cells, business

الوصف: The occurrence of primary cutaneous ganglioneuroma is rare. We report 2 separate cases of primary cutaneous ganglioneuroma, both of which are associated with prominent overlying hyperkeratosis. The first case was in a 38-year-old woman with overlying verrucous keratosis. The second case was in a 93-year-old man with epidermal changes reminiscent of a seborrheic keratosis. Histologically, both lesions were composed of a proliferation of hyperplastic nerve fibers with spindled Schwann cells and axons with intermingled ganglion cells. Immunohistochemistry for neurofilament highlighted nerve fascicles; S100 protein displayed the associated Schwann cells, and neuron-specific enolase stained the interspersed ganglion cells. Variation in immunohistochemical staining was present between the 2 cases. A review of the literature demonstrates variable immunohistochemical staining of ganglion and Schwann cells in prior cases. Familiarity with these findings is important in establishing a diagnosis. The significance of the associated hyperkeratosis remains speculative.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b4557e1365040f3ad4012ccfc4d120Test
https://doi.org/10.1097/dad.0b013e3181834acdTest

المؤلفون: Chelsy L. Marty, John S. Walsh, Henry W. Randle

المصدر: Dermatologic Surgery. 31:780-784

مصطلحات موضوعية: medicine.medical_specialty, Pathology, Skin Neoplasms, Erythema, Administration, Topical, Antineoplastic Agents, Imiquimod, Dermatology, Skin Diseases, Retinoids, Carcinoma, medicine, Humans, Basal cell, Basal cell carcinoma, Adverse effect, Aged, business.industry, General Medicine, Epidermoid cyst, medicine.disease, Safety profile, Treatment Outcome, Carcinoma, Basal Cell, Aminoquinolines, Female, Surgery, Dermatologic Agents, medicine.symptom, business, medicine.drug

الوصف: Background Because of its unique mechanism of action and safety profile, imiquimod, a topical immune response modifier, is used for many benign and malignant dermatologic conditions. Adverse effects are typically limited to treatment site erythema and erosion. Objective To describe a newly recognized adverse effect of imiquimod. Methods A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy. Results Scouting biopsies demonstrated multiple comedones and ruptured epidermoid cysts. There was no evidence of residual basal cell carcinoma. Conclusions Imiquimod is a new and novel treatment option for cutaneous malignancies. We report its successful use in the treatment of a nodular basal cell carcinoma. The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ed2414aff3d75ee2525d0ced4f3380Test
https://doi.org/10.1097/00042728-200507000-00011Test

المؤلفون: S. Walsh, Nighat Arnott, Jon N. Beresford, James Middleton

المصدر: Clinical Orthopaedics and Related Research. 322:224-231

مصطلحات موضوعية: medicine.medical_specialty, Stromal cell, biology, General Medicine, Cell biology, Paracrine signalling, medicine.anatomical_structure, Endocrinology, Growth factor receptor, Giant cell, Osteoclast, Insulin-like growth factor 2, Internal medicine, biology.protein, medicine, Orthopedics and Sports Medicine, Surgery, Growth factor receptor inhibitor, Giant Cell Tumors

الوصف: Insulin-like growth factors I and II are among the most abundant growth factors found in bone, and their expression also has been reported in a variety of neoplastic tissues. Using the technique of in situ hybridization, the authors have studied the expression of the messenger ribonucleic acid (mRNA) for insulin-like growth factors I and II and the Type 1 insulin-like growth factor receptor in giant cell tumors of human bone (n = 8). The expression of the mRNA for insulin-like growth factors I and II and the Type 1 insulin-like growth factor receptor was observed in giant cells and in the mononuclear stromal cell component but not in cells of the fibrous connective tissue at the growing edge of the tumor. The multinucleated cells expressed tartrate resistant acid phosphatase and showed reactivity with osteoclast selective monoclonal antibodies, confirming the close relationship between these giant cells and osteoclasts. Thus, these results are consistent with the possibility that locally produced insulin-like growth factors have an important regulatory role in the growth and development of giant cell tumors of bone. In addition, they suggest that these growth factors may function as autocrine or paracrine regulators of the proliferation and differentiation of cells of the osteoclast lineage.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::de88e253d5a4cb7fb321e212e0902b23Test
https://doi.org/10.1097/00003086-199601000-00027Test

المؤلفون: Henry W. Randle, John S. Walsh, Charles Perniciaro

المصدر: Dermatologic Surgery. 25:49-51

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Skin Neoplasms, Cell, chemistry.chemical_element, Dermatology, Calcium, Medical Records, Dystrophic calcification, Calcium-binding protein, Humans, Medicine, Basal cell, Basal cell carcinoma, Retrospective Studies, business.industry, Calcinosis, General Medicine, medicine.disease, medicine.anatomical_structure, Epidermoid carcinoma, chemistry, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Surgery, business, Calcification

الوصف: Background. Dystrophic calcification refers to calcium deposition occurring in association with local tissue injury or abnormality. Little is known about dystrophic calcification occurring in malignant cutaneous neoplasms. Objective. The purpose of this study was to determine the frequency and pattern of dystrophic calcification occurring in basal cell carcinomas and squamous cell carcinomas. Methods. Consecutive cases (200) of basal cell carcinoma and squamous cell carcinoma were reviewed for evidence of dystrophic calcification. Histologic subtype, location of calcification, and tumor site were noted. Results. Of 200 basal cell carcinomas, 41 (21%) showed evidence of dystrophic calcification, compared with 6 (3%) squamous cell carcinomas. Calcifying basal cell carcinomas were more likely to have a more aggressive histologic subtype and to be located on the trunk. Conclusion. Skin calcium binding protein may be responsible for the calcium deposition and account for the discrepancy seen between the frequency of calcification occurring in basal cell carcinomas and squamous cell carcinomas. As with other tumors with follicular differentiation, calcium deposits were located in keratin-filled cysts. This pattern of dystrophic calcification may be a marker of follicular differentiation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f389ee0771618a2370c7c86d90baa63eTest
https://doi.org/10.1046/j.1524-4725.1999.08141.xTest

المؤلفون: Mona C. Zaher, John S. Walsh, Charles Perniciaro

المصدر: The American Journal of Dermatopathology. 20:613

مصطلحات موضوعية: Crohn's disease, medicine.medical_specialty, business.industry, Dermatology, General Medicine, medicine.disease, Pathology and Forensic Medicine, Giant cell arteritis, medicine, In patient, Sarcoidosis, business, Granuloma annulare

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bdfc8c7b3c73043e88b3f447b03da997Test
https://doi.org/10.1097/00000372-199812000-00117Test