Systemic Lupus Erythematosus Predicts Increased Left Ventricular Mass
| العنوان: | Systemic Lupus Erythematosus Predicts Increased Left Ventricular Mass |
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| المؤلفون: | Janice Pieretti, Richard B. Devereux, Lisa R. Sammaritano, Stephen A. Paget, Joseph E. Schwartz, Jane E. Salmon, Michael D. Lockshin, Daniel M. Levine, Mary J. Roman, Mary K. Crow |
| المصدر: | Circulation. 116:419-426 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Systemic disease, Muscle hypertrophy, Coronary artery disease, Predictive Value of Tests, Physiology (medical), Internal medicine, medicine, Humans, Lupus Erythematosus, Systemic, Registries, Ultrasonography, Lupus erythematosus, Ejection fraction, business.industry, Carotid ultrasonography, Middle Aged, medicine.disease, Connective tissue disease, Arterial stiffness, Cardiology, Female, Hypertrophy, Left Ventricular, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background— Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis and vascular stiffening. Whether SLE alters left ventricular (LV) structure and function in the absence of valvular and clinical coronary artery disease is unknown. Methods and Results— SLE patients without clinical or echocardiographic evidence of valvular or coronary disease were age and gender matched to a reference group (n=173 in both groups). Subjects underwent echocardiography to quantify LV structure and function and carotid ultrasonography to detect atherosclerosis. Disease characteristics and radial applanation tonometry to measure arterial stiffness were evaluated in SLE patients. The 2 groups were similar in subjects’ body size, hypertension and diabetes status, smoking status, and cholesterol levels. LV mass (38.3 versus 32.8 g/m 2.7 ), ejection fraction (71% versus 67%), and prevalence of LV hypertrophy (17.9% versus 6.4%) were higher in SLE patients than in referent subjects (all P P P Conclusions— SLE predicts increased LV mass, possibly because of inflammation-related arterial stiffening. Excess LV hypertrophy may contribute to the increased cardiac morbidity and mortality observed in SLE patients. |
| تدمد: | 1524-4539 0009-7322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9016b1135f893e45709147f6be7e38cTest https://doi.org/10.1161/circulationaha.106.673319Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d9016b1135f893e45709147f6be7e38c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244539 00097322 |
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