Herpes simplex virus-associated acute liver failure: A difficult diagnosis with a poor prognosis
| العنوان: | Herpes simplex virus-associated acute liver failure: A difficult diagnosis with a poor prognosis |
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| المؤلفون: | Faouzi Saliba, Vincent Karam, Didier Samuel, Mylène Sebagh, Denis Castaing, Elisabeth Dussaix, Catherine Guettier, Daniel Azoulay, Anne Marie Roque Afonso, Philippe Ichai, Liana Codes, Maria Eugenia Gonzalez |
| المساهمون: | Centre hépato-biliaire (CHB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Virus Hépatotropes et Cancers, Université Paris-Sud - Paris 11 (UP11)-IFR89-EA 3541, Service de Virologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse, Service d'anatomie pathologique, Hôpital Paul Brousse-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Mony, Claire |
| المصدر: | Liver Transplantation Liver Transplantation, Wiley, 2005, 11, pp.1550-5. ⟨10.1002/lt.20545⟩ |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Biopsy, viruses, medicine.medical_treatment, Acyclovir, MESH: Herpes Simplex, Liver transplantation, Antibodies, Viral, medicine.disease_cause, Chronic liver disease, Gastroenterology, MESH: Biopsy, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Acyclovir, Simplexvirus, Immunohistochemical, 030212 general & internal medicine, MESH: Middle Aged, liver transplantation, MESH: Comparative Study, MESH: Follow-Up Studies, Middle Aged, 3. Good health, Treatment Outcome, Real-time polymerase chain reaction, Superinfection, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, 030211 gastroenterology & hepatology, Adult, MESH: Liver Transplantation, medicine.medical_specialty, Adolescent, Diagnosis, Differential, 03 medical and health sciences, MESH: Diagnosis, Differential, Internal medicine, MESH: Liver Failure, Acute, MESH: Tr, medicine, Humans, MESH: Simplexvirus, Retrospective Studies, MESH: Adolescent, Hepatitis B virus, Hepatitis, Transplantation, MESH: Humans, Hepatology, business.industry, Herpes Simplex, MESH: Retrospective Studies, MESH: Adult, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, acute liver failure, Liver Failure, Acute, herpes simplex virus, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, MESH: Male, real time PCR, Herpes simplex virus, Immunology, Surgery, business, MESH: Female, MESH: Antibodies, Viral, Follow-Up Studies |
| الوصف: | We report 5 cases of acute liver failure related to herpes simplex (HSV) infection in 1 immunocompetent and 4 immunosuppressed patients. One patient was too ill for liver transplantation indication. Three patients, among the 4 listed, underwent liver transplantation. Three patients died 11 days to 1 year after transplantation and 2 patients died 2 to 3 days after admission. All presented with fever and none with skin lesions. The diagnosis of HSV-related hepatitis was made antemortem in only 2 patients on the basis of positive blood cultures and/or immunohistochemic findings. In the remaining patients, HSV diagnosis was made retrospectively on further histologic and virologic investigations. Primary HSV infection was certain or likely in all cases, including an HSV2 superinfection of an anti-HSV1-positive patient and two HSV superinfections of hepatitis B virus (HBV)-related chronic liver disease. In these latter patients, HSV diagnosis was totally unsuspected, despite fever. HSV superinfection has significantly contributed to liver dysfunction aggravation and death. In conclusion, the diagnosis of HSV hepatitis is difficult to establish in the absence of specific clinical signs. This may suggest the need for early administration of acyclovir in patients with suspected HSV hepatitis, without waiting for virologic confirmation. Diagnosis methods providing fast results (real-time polymerase chain reaction [PCR]) should be implemented. |
| وصف الملف: | application/pdf |
| تدمد: | 1527-6473 1527-6465 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b0bd756c27f5c34902412bca597f7bTest https://doi.org/10.1002/lt.20545Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f6b0bd756c27f5c34902412bca597f7b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15276473 15276465 |
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