Low Pressure Plasma Processing of Collagen Membranes for Anti-Cancer Drug Delivery
| العنوان: | Low Pressure Plasma Processing of Collagen Membranes for Anti-Cancer Drug Delivery |
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| المؤلفون: | Alibi Baitukha, Farzaneh Arefi-Khonsari, Marc Pocard, Jerome Pulpytel, Massoud Mirshashi, Azadeh Valinataj-Omran, Iman Al-Dybiat |
| المساهمون: | Laboratoire Interfaces et Systèmes Electrochimiques (LISE), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Carcinose Angiogenèse et Recherche Translationnelle, Angiogenese et recherche translationnelle (CART U965), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Journal of Material Sciences & Engineering Journal of Material Sciences & Engineering, OMICS International, 2018, 7 (6), e1000499-(6p.). ⟨10.4172/2169-0022.1000499⟩ |
| بيانات النشر: | OMICS Publishing Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, plasma polymerization, [SDV.CAN]Life Sciences [q-bio]/Cancer, cell adhesive/repellent coatings, Delivery vehicle, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, medicine, [CHIM]Chemical Sciences, Chemistry, low pressure inductively coupled plasma, [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, technology, industry, and agriculture, Cancer, Biological activity, medicine.disease, Plasma polymerization, Carboplatin, In vitro, 3. Good health, 030104 developmental biology, 030220 oncology & carcinogenesis, Drug delivery, Cancer cell, Biophysics |
| الوصف: | International audience; For targeting the cancer cells, a low pressure ICP reactor was utilised to fabricate a drug delivery system. On the surface of biocompatible collagen membranes, thin plasma polymer coatings were deposited to encapsulate an anticancer drug carboplatin and impart different biologically active functionalities. The characteristics of the deposited films were analysed by FTIR and XPS and the overall functionalities were tested by in vitro and in vivo experiments on the cancer cells lines on the cancer nodules respectively. Preliminary results of fabricated drug delivery systems showed the inhibition of cancer cell proliferation in vitro as well as tumour growth in mice models by 2.8 folds in mass compared to the control case |
| تدمد: | 2169-0022 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10e42c84287747e0966760fe069b295Test https://doi.org/10.4172/2169-0022.1000499Test |
| رقم الانضمام: | edsair.doi.dedup.....b10e42c84287747e0966760fe069b295 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21690022 |
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