Therapeutic potential of Hedgehog signaling inhibitors in cancer: rationale and clinical data
| العنوان: | Therapeutic potential of Hedgehog signaling inhibitors in cancer: rationale and clinical data |
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| المؤلفون: | Blake T. Aftab, Charles M. Rudin |
| المصدر: | Clinical Investigation. 2:371-385 |
| بيانات النشر: | OMICS Publishing Group, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Cyclopamine, business.industry, Cancer, General Medicine, Pharmacology, medicine.disease, Hedgehog signaling pathway, chemistry.chemical_compound, chemistry, Cancer stem cell, Cancer cell, medicine, Cancer research, Basal cell carcinoma, Clinical efficacy, business, Hedgehog |
| الوصف: | The Hedgehog (Hh)-signaling pathway has become recognized as a key therapeutic target in cancer. In addition to a recently approved first-in-class Hh-pathway inhibitor, several other small-molecule Hh inhibitors are currently under clinical investigation in a variety of cancer settings. Hh signaling occurs through both ligand-dependent and -independent signaling mechanisms and has been implicated in tumor propagation, maintenance of cancer cell stem niches, differentiation, metastatic potential and tumor-microenvironment interactions. Hh-pathway inhibitors have shown robust clinical efficacy in diseases driven by ligand-independent pathway activation. However, use of Hh antagonists in this setting may result in acquired drug-resistance. This reality poses interesting challenges for treating drug-resistant neoplasia. The rationales for therapeutic application of Hh-targeting agents beyond ligand-independent diseases are complex, and the positioning of Hh-targeted agents must consider context-dependent cont... |
| تدمد: | 2041-6806 2041-6792 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ea11d09b91b0cd252e05cd9094324126Test https://doi.org/10.4155/cli.12.20Test |
| رقم الانضمام: | edsair.doi...........ea11d09b91b0cd252e05cd9094324126 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20416806 20416792 |
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