رسالة جامعية
Mass Spectrometry-based Fragmentation Chemistry of Small Biological Compounds
| العنوان: | Mass Spectrometry-based Fragmentation Chemistry of Small Biological Compounds |
|---|---|
| المؤلفون: | Guan, Shanshan |
| بيانات النشر: | Ohio University / OhioLINK, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | Ohiolink ETDs |
| Original Material: | http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1616802495967559Test |
| مصطلحات موضوعية: | Chemistry, Mass Spectrometry, Fragmentation, Compounds |
| الوصف: | In this dissertation, the gas-phase fragmentation chemistries of different biological compounds were characterized. We employed the tandem mass spectra of the analytes and detailed density functional theory (DFT) reaction pathway calculations to rationalize the gas-phase fragmentation mechanisms. We investigated the fragmentation characteristics of doubly protonated small peptides of different lengths and compositions (Chapter 2). We studied the fragmentation mechanism of deprotonated peptide that can offer complementary information for the most utilized protonated peptide analysis (Chapter 3). The fragmentation chemistries of different peptidoglycans which were characterized in Chapter 4. In addition, we have developed a method for facile differentiation of acidic, isomeric metabolites by attaching high proton affinity, piperidine-based chemical tags to carboxylic acid groups followed by LC-MS/MS analysis (Chapter 5). |
| Original Identifier: | oai:etd.ohiolink.edu:ohiou1616802495967559 |
| نوع الوثيقة: | Text |
| اللغة: | English |
| الإتاحة: | http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1616802495967559Test |
| حقوق: | unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| رقم الانضمام: | edsndl.OhioLink.oai.etd.ohiolink.edu.ohiou1616802495967559 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |