دورية أكاديمية
Aerobic Training Increases Skin Perfusion by a Nitric Oxide Mechanism in Type 2 Diabetes
| العنوان: | Aerobic Training Increases Skin Perfusion by a Nitric Oxide Mechanism in Type 2 Diabetes |
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| المؤلفون: | Colberg, Sheri R., Hill, Laura C., Parson, Henri K., Thomas, Kathleen S., Vinik, Aaron I. |
| المصدر: | Human Movement Sciences Faculty Publications |
| بيانات النشر: | ODU Digital Commons |
| سنة النشر: | 2010 |
| المجموعة: | Old Dominion University: ODU Digital Commons |
| مصطلحات موضوعية: | Aerobic training, Aerobics, Aspirin, Diabetes, Endothelial-derived hyperpolarizing factor, Microdialysis, Nitric oxide, Original research, Prostaglandins, Skin perfusion, Type 2 diabetes, Endocrinology, and Metabolism, Exercise Science, Sense Organs |
| الوصف: | It is well known that a number of locally released vasodilatory and vasoconstrictive compounds can affect skin perfusion. This study investigated the effects of aerobic training on the contribution of nitric oxide (NO), prostaglandins (PG), and endothelial-derived hyperpolarizing factor (EDHF) in stimulated dorsal foot skin perfusion in individuals with type 2 diabetes (T2DM). Ten previously sedentary, older individuals with T2DM (57.0 ± 3.1 years) and nine sedentary controls (53.5 ± 3.2 years) were tested before and after undertaking six months of moderate aerobic training three times weekly in a supervised setting. All subjects underwent measurement of baseline (32°C) and heat-stimulated (40°C and 44°C) dorsal foot skin perfusion starting one hour after ingestion of a single, oral 325 mg dose of aspirin, a known inhibitor of PG synthesis. Before aspirin ingestion, a subcutaneous microdialysis probe was inserted into each foot dorsum to administer either saline (PG pathway only blocked by aspirin in the left foot) or L-NAME (N(G)-nitro-l-arginine methyl ester; thereby inhibiting both PG and NO pathways in the right foot). Normative data collected previously on subjects undergoing saline administration via microdialysis without aspirin ingestion served as a control group. Significantly lower responsiveness of maximal perfusion was found with the EDHF pathway alone unblocked compared with NO and EDHF unblocked after training. Maximal suppression attributable directly to NO, PG, and EDHF was not significantly different when examined by subject group and training status. However, contributions of NO, PG, and EDHF to maximal perfusion were significantly increased, decreased, and unchanged by aerobic training, respectively, with diabetic and control subjects combined due to nonsignificant differences between groups. Improvements in maximally stimulated dorsal foot skin perfusion resulting from six months of aerobic training appear to have primarily an NO basis, with lesser contributions from PG following ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.odu.edu/hms_fac_pubs/154Test; https://digitalcommons.odu.edu/context/hms_fac_pubs/article/1155/viewcontent/Colberg_2010_AerobicTrainingIncreasesSkinPerfusionOCR.pdfTest |
| الإتاحة: | https://digitalcommons.odu.edu/hms_fac_pubs/154Test https://digitalcommons.odu.edu/context/hms_fac_pubs/article/1155/viewcontent/Colberg_2010_AerobicTrainingIncreasesSkinPerfusionOCR.pdfTest |
| حقوق: | © 2010 Colberg et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| رقم الانضمام: | edsbas.9EFE3888 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |