The associations of triclosan and paraben exposure with allergen sensitization and wheeze in children
| العنوان: | The associations of triclosan and paraben exposure with allergen sensitization and wheeze in children |
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| المؤلفون: | Adam J. Spanier, Tracy Fausnight, Joseph M. Braun, Tareq F. Camacho |
| المصدر: | Allergy and Asthma Proceedings. 35:475-481 |
| بيانات النشر: | Oceanside Publications Inc., 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Allergy, Adolescent, Eczema, Parabens, Allergic sensitization, Atopy, chemistry.chemical_compound, Wheeze, Internal medicine, Hypersensitivity, medicine, Humans, Immunology and Allergy, Public Health Surveillance, Child, Respiratory Sounds, Asthma, business.industry, Articles, General Medicine, Atopic dermatitis, Allergens, medicine.disease, Triclosan, United States, Paraben, Cross-Sectional Studies, Socioeconomic Factors, chemistry, Anti-Infective Agents, Local, Food Preservatives, Female, medicine.symptom, business |
| الوصف: | Triclosan and parabens are chemicals used in personal care and medical products as microbicides and preservatives. Triclosan and paraben exposure may be associated with allergy (atopy), but these associations have not been evaluated with respect to other atopic states such as eczema (atopic dermatitis). This study examines the associations of urinary triclosan and paraben concentrations with allergic sensitization and asthma in children according to eczema history. We performed a cross-sectional analysis of U.S. children aged 6-18 years who participated in the National Health and Nutrition Examination Survey (2005-2006). Triclosan and paraben concentrations were measured in urine. We assessed associations of triclosan and parabens with allergic sensitization and asthma using multivariable logistic regression in 837 children with complete data and stratified our results by eczema status. After covariate adjustment, triclosan and methyl and propyl paraben concentrations were positively associated with the odds of aeroallergen sensitization. Eczema did not significantly modify the association between triclosan or paraben levels and aeroallergen sensitization, asthma, or wheeze. The odds of parent-reported atopic asthma increased 34% (95% CI, 0, 81) across triclosan concentration quartiles. Increasing triclosan concentrations (quartiles) were associated with 2.3 times the odds of food sensitization (95% CI, 1.14, 4.44) among children with eczema, but not among children without eczema (OR, 1.25; 95% CI 0.93, 1.68; effect measure modification, p = 0.04). Triclosan and paraben exposures may increase the risk of atopic asthma and aeroallergen sensitization. Prospective studies are necessary to confirm these findings and determine if these chemicals pose a risk to children's health. |
| تدمد: | 1088-5412 2005-2006 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8ce87939754d572ffffc7205ba6ff0Test https://doi.org/10.2500/aap.2014.35.3803Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da8ce87939754d572ffffc7205ba6ff0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10885412 20052006 |
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