Maternal occupational exposure and congenital heart defects in offspring
| العنوان: | Maternal occupational exposure and congenital heart defects in offspring |
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| المؤلفون: | Spinder, Nynke, Bergman, Jorieke Eh, Kromhout, Hans, Vermeulen, Roel, Corsten-Janssen, Nicole, Boezen, H Marike, du Marchie Sarvaas, Gideon J, de Walle, Hermien Ek, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2 |
| المساهمون: | Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), IRAS OH Epidemiology Chemical Agents, dIRAS RA-2 |
| المصدر: | Scandinavian Journal of Work, Environment & Health, Vol 46, Iss 6, Pp 599-608 (2020) Scandinavian Journal of Work, Environment & Health Scandinavian Journal of Work, Environment & Health, 46(6), 599. Finnish Institute of Occupational Health Scandinavian Journal of Work, Environment & Health, 46(6), 599-608. SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH |
| بيانات النشر: | Nordic Association of Occupational Safety and Health (NOROSH), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Pregnancy, Maternal-Fetal Exchange, Netherlands, mineral dust, Minerals, Obstetrics, mother, Dust, metal fume, Middle Aged, heart defect, Metals, Prenatal Exposure Delayed Effects, Female, Original Article, Public aspects of medicine, RA1-1270, Cohort study, Adult, Heart Defects, Congenital, medicine.medical_specialty, Adolescent, Offspring, Job-exposure matrix, Air Pollutants, Occupational, Lower risk, solvent, congenital heart defect, Young Adult, work, maternal exposure, medicine, Humans, maternal occupational exposure, Pesticides, pesticide, metal gas, offspring, business.industry, Public Health, Environmental and Occupational Health, Infant, Newborn, Odds ratio, occupational exposure, medicine.disease, organic dust, Stenosis, maternal, Case-Control Studies, Pulmonary valve stenosis, maternal characteristic, Solvents, business |
| الوصف: | OBJECTIVES: Congenital heart defects (CHD) are the most prevalent congenital anomalies. This study aims to examine the association between maternal occupational exposures to organic and mineral dust, solvents, pesticides, and metal dust and fumes and CHD in the offspring, assessing several subgroups of CHD. METHODS: For this case–control study, we examined 1174 cases with CHD from EUROCAT Northern Netherlands and 5602 controls without congenital anomalies from the Lifelines cohort study. Information on maternal jobs held early in pregnancy was collected via self-administered questionnaires, and job titles were linked to occupational exposures using a job exposure matrix. RESULTS: An association was found between organic dust exposure and coarctation of aorta [adjusted odds ratio (OR_adj) 1.90, 95% confidence interval (CI) 1.01–3.59] and pulmonary (valve) stenosis in combination with ventricular septal defect (OR_adj 2.68, 95% CI 1.07–6.73). Mineral dust exposure was associated with increased risk of coarctation of aorta (OR_adj 2.94, 95% CI 1.21–7.13) and pulmonary valve stenosis (OR_adj 1.99, 95% CI 1.10–3.62). Exposure to metal dust and fumes was infrequent but was associated with CHD in general (OR_adj 2.40, 95% CI 1.09–5.30). Exposure to both mineral dust and metal dust and fumes was associated with septal defects (OR_adj 3.23, 95% CI 1.14–9.11). Any maternal occupational exposure was associated with a lower risk of aortic stenosis (OR_adj 0.32, 95% CI 0.11–0.94). CONCLUSIONS: Women should take preventive measures or avoid exposure to mineral and organic dust as well as metal dust and fumes early in pregnancy as this could possibly affect foetal heart development. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0355-3140 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f788dd39b9088859c3598ddbeab8561aTest https://doaj.org/article/958bfcd2baa1465898db02e8369fdbaeTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f788dd39b9088859c3598ddbeab8561a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03553140 |
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