Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study
| العنوان: | Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study |
|---|---|
| المؤلفون: | Lenka Foretova, Marcello Campagna, Ilaria Pilia, Giannina Satta, Federico Meloni, Silvia de Sanjosé, Fahad Ahmed, Anthony Staines, Sara De Matteis, Delphine Casabonne, Alexandra Nieters, Nikolaus Becker, Mariagrazia Zucca, Marc Maynadié, Andrea 't Mannetje, Maria Grazia Ennas, Yolanda Benavente, Pierluigi Cocco |
| المصدر: | Scandinavian Journal of Work, Environment & Health, Vol 47, Iss 1, Pp 42-51 (2021) Scandinavian Journal of Work, Environment & Health Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | Nordic Association of Occupational Safety and Health (NOROSH), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Limfomes, hodgkin lymphoma, Epidemiology, Follicular lymphoma, Cumulative Exposure, lymphoma, wood dust, leather dust, Risk Factors, Environmental health, medicine, Humans, B-cell lymphoma, Epidemiologia, lymphoma subtype, business.industry, textile dust, flour dust, Public Health, Environmental and Occupational Health, Case-control study, Dust, case–control study, occupational exposure, medicine.disease, organic dust, Confidence interval, Lymphoma, Malaltia de Hodgkin, Occupational Diseases, Case-Control Studies, Original Article, b cell lymphoma, epidemiology, Lymphomas, Occupational exposure, epilymph, Hodgkin's disease, Public aspects of medicine, RA1-1270, business |
| الوصف: | Objectives: This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts. Methods: We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case–control study, conducted in six European countries in 1998–2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any types) groups: wood and textile dusts. Risk was predicted with unconditional regression modeling, adjusted by age, gender, study center, and education. Results: We observed a 2.1-fold increase in risk of follicular lymphoma associated with ever exposure to leather dust [95% confidence interval (CI) 1.01–4.20]. After excluding subjects who ever worked in a farm or had ever been exposed to solvents, risk of B-cell lymphoma was elevated in relation to ever exposure to leather dust [odd ratio (OR) 2.2, 95% CI 1.00–4.78], but it was not supported by increasing trends with the exposure metrics. Risk of Hodgkin lymphoma was elevated (OR 2.0, 95% CI 0.95–4.30) for exposure to textile dust, with consistent upward trends by cumulative exposure and three independent exposure metrics combined (P=0.023, and P=0.0068, respectively). Conclusions: Future, larger studies might provide further insights into the nature of the association we observed between exposure to textile dust and risk of Hodgkin lymphoma. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e1d602deac86dbb94570c237bbe521Test http://hdl.handle.net/2445/173747Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....77e1d602deac86dbb94570c237bbe521 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |