دورية أكاديمية
Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
| العنوان: | Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. |
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| المؤلفون: | Martineau, AR, Jolliffe, DA, Greenberg, L, Aloia, JF, Bergman, P, Dubnov-Raz, G, Esposito, S, Ganmaa, D, Ginde, AA, Goodall, EC, Grant, CC, Janssens, W, Jensen, ME, Kerley, CP, Laaksi, I, Manaseki-Holland, S, Mauger, D, Murdoch, DR, Neale, R, Rees, JR, Simpson, S, Stelmach, I, Trilok Kumar, G, Urashima, M, Camargo, CA, Griffiths, CJ, Hooper, RL |
| بيانات النشر: | NIHR Journals Library |
| سنة النشر: | 2019 |
| المجموعة: | Queen Mary University of London: Queen Mary Research Online (QMRO) |
| الوصف: | BACKGROUND: Randomised controlled trials (RCTs) exploring the potential of vitamin D to prevent acute respiratory infections have yielded mixed results. Individual participant data (IPD) meta-analysis has the potential to identify factors that may explain this heterogeneity. OBJECTIVES: To assess the overall effect of vitamin D supplementation on the risk of acute respiratory infections (ARIs) and to identify factors modifying this effect. DATA SOURCES: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, ClinicalTrials.gov and the International Standard Randomised Controlled Trials Number (ISRCTN) registry. STUDY SELECTION: Randomised, double-blind, placebo-controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration having incidence of acute respiratory infection as a prespecified efficacy outcome were selected. STUDY APPRAISAL: Study quality was assessed using the Cochrane Collaboration Risk of Bias tool to assess sequence generation, allocation concealment, blinding of participants, personnel and outcome assessors, completeness of outcome data, evidence of selective outcome reporting and other potential threats to validity. RESULTS: We identified 25 eligible RCTs (a total of 11,321 participants, aged from 0 to 95 years). IPD were obtained for 10,933 out of 11,321 (96.6%) participants. Vitamin D supplementation reduced the risk of ARI among all participants [adjusted odds ratio (aOR) 0.88, 95% confidence interval (CI) 0.81 to 0.96; heterogeneity p < 0.001]. Subgroup analysis revealed that protective effects were seen in individuals receiving daily or weekly vitamin D without additional bolus doses (aOR 0.81, 95% CI 0.72 to 0.91), but not in those receiving one or more bolus doses (aOR 0.97, 95% CI 0.86 to 1.10; p = 0.05). Among those receiving daily or weekly vitamin D, protective effects of vitamin D were stronger in individuals with a baseline 25-hydroxyvitamin D [25(OH)D] concentration of < 25 nmol/l (aOR 0.30, 95% CI 0.17 to 0.53) than ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 - 44 |
| اللغة: | English |
| العلاقة: | Health Technol Assess; Martineau AR, Jolliffe DA, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, et al. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. Health Technol Assess 2019;23(2).; https://qmro.qmul.ac.uk/xmlui/handle/123456789/56757Test |
| DOI: | 10.3310/hta23020 |
| الإتاحة: | https://doi.org/10.3310/hta23020Test https://qmro.qmul.ac.uk/xmlui/handle/123456789/56757Test |
| رقم الانضمام: | edsbas.BE0C2E60 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3310/hta23020 |
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