التفاصيل البيبلوغرافية
| العنوان: |
"Masked Il12 Fusion Proteins And Methods Of Use Thereof" in Patent Application Approval Process (USPTO 20230122079). |
| المصدر: |
Cancer Vaccine Week; 5/8/2023, p61-61, 1p |
| مصطلحات موضوعية: |
CHIMERIC proteins, PATENT applications, PATENT offices, TRYPTASE, AMINO acid sequence, CARBOXYPEPTIDASES |
| مستخلص: |
The masked IL12 fusion protein of claim 13, wherein the IL12 polypeptide comprises the p40 polypeptide amino acid sequence set forth in SEQ ID NO:22 and the p35 IL12 polypeptide is non-covalently bound to the p40 polypeptide. The masked IL12 fusion protein of claim 20, wherein the masking moiety is an IL12Rb1 or an IL12-binding fragment thereof; and wherein the IL12 fusion protein further comprises a second masking moiety comprising an IL12Rb2 or an IL12-binding fragment thereof fused by a fourth linker to the p35 domain of the IL12 polypeptide. The masked IL12 fusion protein of claim 13, wherein the IL12 polypeptide comprises the p35 polypeptide amino acid sequence set forth in SEQ ID NO:23 and the p40 IL12 polypeptide is non-covalently bound to the p40 polypeptide. The masked IL12 fusion protein of claim 1, wherein the IL12 polypeptide is a single chain IL12 polypeptide selected from a single chain IL12 polypeptide having the orientation p35-linker-p40 or p40-linker-p35. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
