دورية أكاديمية
Association between lipoprotein(a) and nonalcoholic fatty liver disease among Korean adults
| العنوان: | Association between lipoprotein(a) and nonalcoholic fatty liver disease among Korean adults |
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| المساهمون: | College of Medicine, Dept. of Internal Medicine, Ji Sun Nam, Sehee Jo, Shinae Kang, ChulWoo Ahn, Kyung Rae Kim, Jong Suk Park, Kang, Shin Ae, Kim, Kyung Rae, Nam, Ji Sun, Park, Jong Suk, Ahn, Chul Woo, Jo, Se Hee |
| بيانات النشر: | Elsevier Netherlands |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Cross-Sectional Studies, Female, Humans, Lipoproteins/blood, Male, Middle Aged, Non-alcoholic Fatty Liver Disease/blood, Regression Analysis, Republic of Korea, Risk Factors, Insulin resistance, Lipoprotein(a), Nonalcoholic fatty liver disease |
| الوصف: | BACKGROUND: Lipoprotein(a) [Lp(a)] and nonalcoholic fatty liver disease (NAFLD) are risk factors for cardiovascular diseases. We investigated the relationship between Lp(a) concentrations and NAFLD among Korean adults. METHODS: A total of 2242 nondiabetic subjects undergoing routine health screening examination were enrolled. Anthropometric and biochemical parameters, including Lp(a) were measured. NAFLD were assessed by ultrasonography. Adjusted Odds ratios for the presence of NAFLD according to Lp(a) tertiles were estimated using logistic regression. RESULTS: Subjects were grouped according to the severity of NAFLD and Lp(a) concentrations. Lp(a) concentrations were decreased across the severity of NAFLD and the prevalence of NAFLD decreased with the Lp(a) tertiles. Compared with subjects in the lowest tertile of Lp(a), those in the highest tertile had higher total cholesterol and LDL-C concentrations and lower body mass index, blood pressure, fasting glucose, triglyceride, ALT, and HOMA-IR concentrations. In the logistic regression analysis after adjusting for multiple risk factors, the relationship between Lp(a) concentrations and the presence of NAFLD remained significant. However, this association was attenuated after adjusting for insulin resistance. CONCLUSIONS: Lp(a) was inversely associated with the presence of NAFLD, but it was not an independent risk factor for NAFLD among Korean adults. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0009-8981 1873-3492 27394182 |
| العلاقة: | CLINICA CHIMICA ACTA; J00543; OAK-2016-04918; https://ir.ymlib.yonsei.ac.kr/handle/22282913/151888Test; http://www.sciencedirect.com/science/article/pii/S0009898116303023?via%3DihubTest; T201603249; CLINICA CHIMICA ACTA, Vol.461 : 14-18, 2016 |
| DOI: | 10.1016/j.cca.2016.07.003 |
| الإتاحة: | https://doi.org/10.1016/j.cca.2016.07.003Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/151888Test http://www.sciencedirect.com/science/article/pii/S0009898116303023?via%3DihubTest |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.40D896BF |
| قاعدة البيانات: | BASE |
| تدمد: | 00098981 18733492 27394182 |
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| DOI: | 10.1016/j.cca.2016.07.003 |