دورية أكاديمية
Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
| العنوان: | Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features |
|---|---|
| المؤلفون: | Dejima, Hitoshi, Hu, Xin, Chen, Runzhe, Zhang, Jiexin, Fujimoto, Junya, Parra, Edwin R, Haymaker, Cara, Hubert, Shawna M, Duose, Dzifa, Solis, Luisa M, Su, Dan, Fukuoka, Junya, Tabata, Kazuhiro, Pham, Hoa HN, Mcgranahan, Nicholas, Zhang, Baili, Ye, Jie, Ying, Lisha, Little, Latasha, Gumbs, Curtis, Chow, Chi-Wan, Estecio, Marcos Roberto, Godoy, Myrna CB, Antonoff, Mara B, Sepesi, Boris, Pass, Harvey, Behrens, Carmen, Zhang, Jianhua, Vaporciyan, Ara A, Heymach, John, Scheet, Paul, Lee, J Jack, Wu, Jia, Futreal, P Andrew, Reuben, Alexandre, Kadara, Humam, Wistuba, Ignacio I, Zhang, Jianjun |
| المصدر: | Nature Communications , 12 (1) , Article 2722. (2021) |
| بيانات النشر: | NATURE RESEARCH |
| سنة النشر: | 2021 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell receptor (TCR) sequencing and multiplex immunofluorescence (mIF). Our results demonstrate that anti-tumor immunity evolved as a continuum from lung preneoplasia, to preinvasive ADC, minimally-invasive ADC and frankly invasive lung ADC with a gradually less effective and more intensively regulated immune response including down-regulation of immune-activation pathways, up-regulation of immunosuppressive pathways, lower infiltration of cytotoxic T cells (CTLs) and anti-tumor helper T cells (Th), higher infiltration of regulatory T cells (Tregs), decreased T cell clonality, and lower frequencies of top T cell clones in later-stages. Driver mutations, chromosomal copy number aberrations (CNAs) and aberrant DNA methylation may collectively impinge host immune responses and facilitate immune evasion, promoting the outgrowth of fit subclones in preneoplasia into dominant clones in invasive ADC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10160828/1/s41467-021-22890-x.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10160828Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10160828/1/s41467-021-22890-x.pdfTest https://discovery.ucl.ac.uk/id/eprint/10160828Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.283F2AA6 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |