دورية أكاديمية
Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease
| العنوان: | Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease |
|---|---|
| المؤلفون: | Ramachandran, Dhanya, Tyrer, Jonathan P., Kommoss, Stefan, DeFazio, Anna, Riggan, Marjorie J., Webb, Penelope M., Fasching, Peter A., Lambrechts, Diether, García, María J., Rodríguez-Antona, Cristina, Goodman, Marc T., Modugno, Francesmary, Moysich, Kirsten B., Karlan, Beth Y., Lester, Jenny, Kjaer, Susanne K., Jensen, Allan, Høgdall, Estrid, Goode, Ellen L., Cliby, William A., Kumar, Amanika, Wang, Chen, Cunningham, Julie M., Winham, Stacey J., Monteiro, Alvaro N., Schildkraut, Joellen M., Cramer, Daniel W., Terry, Kathryn L., Titus, Linda, Bjorge, Line, Thomsen, Liv Cecilie Vestrheim, Pejovic, Tanja, Høgdall, Claus K., Mcneish, Iain A., May, Taymaa, Huntsman, David G., Pfisterer, Jacobus, Canzler, Ulrich, Park-Simon, Tjoung-Won, Schröder, Willibald, Belau, Antje, Hanker, Lars, Harter, Philipp, Sehouli, Jalid, Kimmig, Rainer, de Gregorio, Nikolaus, Schmalfeldt, Barbara, Baumann, Klaus, Hilpert, Felix, Burges, Alexander, Winterhoff, Boris, Schürmann, Peter, Speith, Lisa-Marie, Hillemanns, Peter, Berchuck, Andrew, Johnatty, Sharon E., Ramus, Susan J., Chenevix-Trench, Georgia, Pharoah, Paul D.P., Dörk, Thilo, Heitz, Florian |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2024 |
| المجموعة: | University of Glasgow: Enlighten - Publications |
| الوصف: | Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection status of 7705 ovarian cancer patients, including 4954 with high-grade serous carcinoma (HGSOC), to identify variants associated with residual disease. The most significant association with resection status was observed for rs72845444, upstream of MGMT, in HGSOC (p = 3.9 × 10−8). In gene-based analyses, PPP2R5C was the most strongly associated gene in HGSOC after stage adjustment. In an independent set of 378 ovarian tumours from the AGO-OVAR 11 study, variants near MGMT and PPP2R5C correlated with methylation and transcript levels, and PPP2R5C mRNA levels predicted progression-free survival in patients with residual disease. MGMT encodes a DNA repair enzyme, and PPP2R5C encodes the B56γ subunit of the PP2A tumour suppressor. Our results link heritable variation at these two loci with resection status in HGSOC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://eprints.gla.ac.uk/322186/2/322186.pdfTest; Ramachandran, D. et al. (2024) Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease. npj Genomic Medicine , 9(1), 19. (doi:10.1038/s41525-024-00395-y ) (PMID:38443389) (PMCID:PMC10915171) |
| الإتاحة: | https://doi.org/10.1038/s41525-024-00395-yTest https://eprints.gla.ac.uk/322186Test/ https://eprints.gla.ac.uk/322186/2/322186.pdfTest |
| حقوق: | cc_by_4 |
| رقم الانضمام: | edsbas.B9193795 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |