التفاصيل البيبلوغرافية
العنوان:
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
المؤلفون:
Francois Bacot , Julie M. Cunningham , Shelley S. Tworoger , Robert S. Brown , Allan Jensen , Anja Rudolph , Jonathan Tyrer , Edwin S. Iversen , Tanja Pejovic , Lynne R. Wilkens , Sebastian M. Armasu , Alice S. Whittemore , Florian Heitz , Beth Y. Karlan , Yin Ling Woo , Karen Lu , Heather S. L. Jim , Bohdan Górski , Wei Zheng , Harvey A. Risch , Hui-Yi Lin , Arif B. Ekici , Rosalind Glasspool , Kimberly R. Kalli , Diether Lambrechts , Nathan Lee , Toru Nakanishi , Diana Eccles , Gottfried E. Konecny , Ian G. Campbell , Heli Nevanlinna , Thomas A. Sellers , Jin Q. Cheng , Agnieszka Dansonka-Mieszkowska , Argyrios Ziogas , Matthias W. Beckmann , Michael J. Birrer , Melissa C. Southey , Liisa M. Pelttari , Jolanta Kupryjanczyk , Camilla Krakstad , Elizabeth M. Poole , Robert A. Vierkant , Xiao-Ou Shu , Nicolas Wentzensen , Fumitaka Kikkawa , Y. Ann Chen , Celeste Leigh Pearce , Howard C. Shen , Allison F. Vitonis , Ya-Yu Tsai , Gerhard A. Coetzee , Jolanta Lissowska , Sandrina Lambrechts , Dong Liang , Kathryn L. Terry , Hannah P. Yang , Graham G. Giles , Daniel C. Tessier , Ira Schwaab , Anna H. Wu , Hoda Anton-Culver , Gianluca Severi , Stephen J. Chanock , Douglas F. Easton , Weiva Sieh , Natalia Antonenkova , Anne M. van Altena , Keitaro Matsuo , Anna Jakubowska , Paul D.P. Pharoah , Peter Hillemanns , Qiuyin Cai , Susanne K. Kjaer , Katja K.H. Aben , Kirsten B. Moysich , Estrid Høgdall , Ellen L. Goode , Lambertus A. Kiemeney , David Fenstermacher , Xiaotao Qu , Jesus Gonzalez-Bosquet , Daniel O. Stram , Irene Orlow , Joellen M. Schildkraut , Antonis C. Antoniou , Rachel Palmieri Weber , Satoyo Hosono , Jie Lin , Roberta B. Ness , Shan Wang-Gohrke , Simon A. Gayther , James Paul , Jill S. Barnholtz-Sloan , Usha Menon , Johnathan M. Lancaster , Jennifer A. Doherty , Stefan Nickels , Paola Raska , Jan Lubinski , Boon Kiong Lim , Elisabeth Wik , Aleksandra Gentry-Maharaj , Kate Lawrenson , Georgia Chenevix-Trench , Maureen E. Hoatlin , Stanley B. Kaye , Lotte Nedergaard , Natalia Bogdanova , Zhihua Chen , Janet M. Lee , Laura Baglietto , Francesmary Modugno , Linda E. Kelemen , Elisa V. Bandera , Montserrat Garcia-Closas , Helga B. Salvesen , Brooke L. Fridley , Rod Karevan , Houtan Noushmehr , Thilo Dörk , Ralf Bützow , Nhu D. Le , Douglas A. Levine , Sara H. Olson , Mine S. Cicek , Louise A. Brinton , Soo-Hwang Teo , Ignace Vergote , Pamela J. Thompson , Catherine M. Phelan , Marc T. Goodman , Linda S. Cook , Matthias Dürst , Malcolm C. Pike , Boris Winterhoff , Mari K. Halle , Andreas du Bois , Daniel Vincent , Valerie McGuire , Rebecca Sutphen , Peter A. Fasching , Jenny Chang-Claude , Stefan P. Renner , Jennifer Permuth-Wey , Aneliya Velkova , John McLaughlin , Kunle Odunsi , Greg Bloom , Leon F.A.G. Massuger , Arto Leminen , Melissa C. Larson , Iwona K. Rzepecka , Philipp Harter , Beata Spiewankiewicz , Mary Anne Rossing , Jacek Gronwald , Yurii B. Shvetsov , Claus Høgdall , Martin Gore , Angela Brooks-Wilson , Evelyn Despierre , Fergus J. Couch , Vijayalakshmi Shridhar , Ingo B. Runnebaum , James M. Flanagan , Galina Lurie , Alvaro N.A. Monteiro , Per Hall , Andrew Berchuck , Robert Edwards , Yong-Bing Xiang , Honglin Song , Susan J. Ramus , Famida Zulkifli , Lorna Rodriguez-Rodriguez , Steven A. Narod , Daniel W. Cramer
المساهمون:
Cancer Research UK
المصدر:
Nature Communications, 4, pp. 1627-1627
بيانات النشر:
NATURE RESEARCH, 2013.
سنة النشر:
2013
مصطلحات موضوعية:
Genetics and Molecular Biology (all) , endocrine system diseases , General Physics and Astronomy , Genome-wide association study , Australian Ovarian Cancer Study , Aetiology, screening and detection [ONCOL 5] , Female , Humans , Neoplasms, Glandular and Epithelial , Ovarian Neoplasms , Polymorphism, Single Nucleotide , Chromosomes, Human, Pair 17 , Genetic Predisposition to Disease , Chemistry (all) , Biochemistry, Genetics and Molecular Biology (all) , Physics and Astronomy (all) , Carcinoma, Ovarian Epithelial , SITE POLYMORPHISMS , Biochemistry , 0302 clinical medicine , Polymorphism (computer science) , Neoplasms , Ovarian Epithelial , Consortium of Investigators of Modifiers of BRCA1/2 , GENETIC-VARIANTS , 2.1 Biological and endogenous factors , Aetiology , Cancer , Genetics , Midical sciences: 700::Clinical medical sciences: 750::Gynaecology and obstetrics: 756 [VDP] , RISK , 0303 health sciences , COMMON INVERSION , Multidisciplinary , Glandular and Epithelial , Single Nucleotide , Aetiology, screening and detection Immune Regulation [ONCOL 5] , female genital diseases and pregnancy complications , 3. Good health , Ovarian Cancer , Multidisciplinary Sciences , GENÉTICA , 030220 oncology & carcinogenesis , Science & Technology - Other Topics , FUNCTIONAL ANNOTATION , Human , Biotechnology , Biology , Medisinske fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 [VDP] , BINDING-SITES , General Biochemistry, Genetics and Molecular Biology , Article , Chromosomes , 03 medical and health sciences , Rare Diseases , Translational research [ONCOL 3] , Australian Cancer Study , MD Multidisciplinary , medicine , Polymorphism , GENOME-WIDE ASSOCIATION , Genotyping , PARKINSON-DISEASE , MAPT REGION , 030304 developmental biology , Molecular epidemiology Aetiology, screening and detection [NCEBP 1] , Science & Technology , Molecular epidemiology , Hereditary cancer and cancer-related syndromes [ONCOL 1] , MULTIDISCIPLINARY SCIENCES , MICRORNA EXPRESSION , Pair 17 , Carcinoma , Human Genome , General Chemistry , Odds ratio , medicine.disease , Human genome , Ovarian cancer
الوصف:
Contains fulltext : 118576.pdf (Publisher’s version ) (Open Access) Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (odds ratio=1.12, P=10(-8)) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion (P=10(-10)). Variation at 17q21.31 is associated with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes.
وصف الملف:
Print; application/pdf
اللغة:
English
تدمد:
2041-1723
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cc08221bb4011d7aa869a08f21333aTest https://lirias.kuleuven.be/handle/123456789/624833Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....e0cc08221bb4011d7aa869a08f21333a
قاعدة البيانات:
OpenAIRE
