مورد إلكتروني
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
| العنوان: | SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes |
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| بيانات النشر: | KTH, Science for Life Laboratory, SciLifeLab KTH, Genteknologi KTH Nature Research 2020 |
| تفاصيل مُضافة: | Sungnak, W. Huang, N. Bécavin, C. Berg, M. Queen, R. Litvinukova, M. Talavera-López, C. Maatz, H. Reichart, D. Sampaziotis, F. Worlock, K. B. Yoshida, M. Barnes, J. L. Banovich, N. E. Barbry, P. Brazma, A. Collin, J. Desai, T. J. Duong, T. E. Eickelberg, O. Falk, C. Farzan, M. Glass, I. Gupta, R. K. Haniffa, M. Horvath, P. Hubner, N. Hung, D. Kaminski, N. Krasnow, M. Kropski, J. A. Kuhnemund, M. Lako, M. Lee, H. Leroy, S. Linnarson, S. Lundeberg, Joakim Meyer, K. B. Miao, Z. Misharin, A. V. Nawijn, M. C. Nikolic, M. Z. Noseda, M. Ordovas-Montanes, J. Oudit, G. Y. Pe’er, D. Powell, J. Quake, S. Rajagopal, J. Tata, P. R. Rawlins, E. L. Regev, A. Reyfman, P. A. Rozenblatt-Rosen, O. Saeb-Parsy, K. Samakovlis, Christos Schiller, H. B. Schultze, J. L. Seibold, M. A. Seidman, C. E. Seidman, J. G. Shalek, A. K. Shepherd, D. Spence, J. Spira, A. Sun, X. Teichmann, S. A. Theis, F. J. Tsankov, A. M. Vallier, L. van den Berge, M. Whitsett, J. Xavier, R. Xu, Y. Zaragosi, L. -E Zerti, D. Zhang, H. Zhang, K. Rojas, M. Figueiredo, F. Network, HCA Lung Biological |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. QC 20200625 |
| مصطلحات الفهرس: | angiotensin converting enzyme 2, atp10b protein, c15orf48 protein, cathepsin B, cathepsin L, cdc42ep5 protein, crym protein, cyp2f1 protein, duoxa2 protein, fam3d protein, fcgbp protein, ido1 protein, lypd2 protein, messenger RNA, mx1 protein, oas1 protein, prkar2b protein, prostate stem cell antigen, protein, protein S 100, proteinase, rarres1 protein, slc5a8 protein, spdef protein, st3gal4 enzyme, st6gal1 enzyme, tmprss2 protein, ube2l6 protein, unclassified drug, virus enzyme, vitronectin, Article, colon tissue, comparative study, cornea epithelium, cornea tissue, coronavirus disease 2019, epithelium cell, esophagus tissue, fetus, fetus tissue, gene expression, gene expression level, heart tissue, human, human cell, human tissue, ileum tissue, immune response gene, innate immunity, kidney tissue, liver tissue, marker gene, muscle tissue, nose epithelium, pancreas tissue, priority journal, prostate tissue, retina tissue, Severe acute respiratory syndrome coronavirus 2, single cell RNA seq, skeletal muscle, spleen tissue, testis tissue, viral tropism, virus entry, virus transmission, Medical and Health Sciences, Medicin och hälsovetenskap, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1038.s41591-020-0868-6 |
| URL: | Nature Medicine, 1078-8956, 2020, 26:5, s. 681-687 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UPE oai:DiVA.org:kth-273986 0000-0003-4313-1601 doi:10.1038/s41591-020-0868-6 PMID 32327758 ISI:000528517900001 Scopus 2-s2.0-85083969210 1235046488 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1235046488 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1038.s41591-020-0868-6 |
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