دورية أكاديمية
Radioguided surgery with β− radiation in pancreatic Neuroendocrine tumors: a feasibility study
| العنوان: | Radioguided surgery with β− radiation in pancreatic Neuroendocrine tumors: a feasibility study |
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| المؤلفون: | Collamati, F., Maccora, D., Alfieri, S., Bocci, V, Cartoni, A., Collarino, A., De Simoni, M., Fischetti, M., Fratoddi, I., Giordano, A., Mancini-Terracciano, C., Mirabelli, R., Morganti, S., Quero, G., Rotili, D., Scotognella, T., Solfaroli Camillocci, E., Traini, G., Venditti, I., Faccini, R. |
| المساهمون: | Collamati, F., Maccora, D., Alfieri, S., Bocci, V, Cartoni, A., Collarino, A., De Simoni, M., Fischetti, M., Fratoddi, I., Giordano, A., Mancini-Terracciano, C., Mirabelli, R., Morganti, S., Quero, G., Rotili, D., Scotognella, T., Solfaroli Camillocci, E., Traini, G., Venditti, I., Faccini, R. |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2020 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | applied physic, oncology, preclinical research, translational research |
| الوصف: | the possibility to use β− decaying isotopes for radioguided surgery (RGS) has been recently proposed, and first promising tests on ex-vivo samples of Meningioma and intestinal neuroendocrine tumor (net) have been published. this paper reports a study of the uptake of 68Ga-DOTATOC in pancreatic nets (pnets) in order to assess the feasibility of a new RGS approach using 90Y-DOTATOC. Tumor and healthy pancreas uptakes were estimated from 68Ga-DOTATOC PET/CT scans of 30 patients with pNETs. From the obtained SUVs (Standardised Uptake Value) and TNRs (Tumor Non tumor Ratio), an analysis algorithm relying on a Monte carlo simulation of the detector has been applied to evaluate the performances of the proposed technique. Almost all considered patients resulted to be compatible with the application of β−-RGS assuming to administer 1.5 MBq/kg of activity of 90Y-DOTATOC 24 h before surgery, and a sampling time of few seconds. In just 2 cases the technique would have required a mildly increased amount of activity or of sampling time. Despite a high physiological uptake of 68Ga-DOTATOC in the healthy pancreas, the proposed RGS technique promises to be effective. This approach allows RGS to find application also in pancreatic diseases, where traditional techniques are not viable. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000563275200010; volume:10; issue:1; firstpage:1; lastpage:10; numberofpages:10; journal:SCIENTIFIC REPORTS; https://hdl.handle.net/11573/1387842Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85080868854 |
| DOI: | 10.1038/s41598-020-61075-2 |
| الإتاحة: | https://doi.org/10.1038/s41598-020-61075-2Test https://hdl.handle.net/11573/1387842Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6DCE3766 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-020-61075-2 |
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