دورية أكاديمية
Clustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggers
| العنوان: | Clustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggers |
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| المؤلفون: | Rypdal, Martin wibe, Rypdal, Veronika Gjertsen, Burney, Jennifer A., Cayan, Daniel, Bainto, Emelia, Skochko, Shannon, Tremoulet, Adriana H., Creamean, Jessie, Shimizu, Chisato, Kim, Ji-Hoon, Burns, Jane C. |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2018 |
| المجموعة: | University of Tromsø: Munin Open Research Archive |
| مصطلحات موضوعية: | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
| الوصف: | Source at https://doi.org/10.1038/s41598-018-33124-4Test . ; Kawasaki Disease (KD) is the most common cause of pediatric acquired heart disease, but its etiology remains unknown. We examined 1164 cases of KD treated at a regional children’s hospital in San Diego over a period of 15 years and uncovered novel structure to disease incidence. KD cases showed a well-defined seasonal variability, but also clustered temporally at much shorter time scales (days to weeks), and spatiotemporally on time scales of up to 10 days and spatial scales of 10–100 km. Temporal clusters of KD cases were associated with strongly significant regional-scale air temperature anomalies and consistent larger-scale atmospheric circulation patterns. Gene expression analysis further revealed a natural partitioning of KD patients into distinct groups based on their gene expression pattern, and that the different groups were associated with certain clinical characteristics that also exhibit temporal autocorrelation. Our data suggest that one or more environmental triggers exist, and that episodic exposures are modulated at least in part by regional weather conditions. We propose that characterization of the environmental factors that trigger KD in genetically susceptible children should focus on aerosols inhaled by patients who share common disease characteristics. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | Scientific Reports; Rypdal, M.W., Rypdal, V.G., Burney, J.A., Cayan, D., Bainto, E., Skochko, S., . Burns, J.C. (2018). Clustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggers. Scientific Reports, 8 , 16140. https://doi.org/10.1038/s41598-018-33124-4Test; FRIDAID 1647978; https://hdl.handle.net/10037/14828Test |
| DOI: | 10.1038/s41598-018-33124-4 |
| الإتاحة: | https://doi.org/10.1038/s41598-018-33124-4Test https://hdl.handle.net/10037/14828Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.3FF60E3B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-018-33124-4 |