دورية أكاديمية
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
| العنوان: | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. |
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| المؤلفون: | Tomlinson, Ian PM, Webb, Emily, Carvajal-Carmona, Luis, Broderick, Peter, Howarth, Kimberley, Pittman, Alan M, Spain, Sarah, Lubbe, Steven, Walther, Axel, Sullivan, Kate, Jaeger, Emma, Fielding, Sarah, Rowan, Andrew, Vijayakrishnan, Jayaram, Domingo, Enric, Chandler, Ian, Kemp, Zoe, Qureshi, Mobshra, Farrington, Susan M, Tenesa, Albert, Prendergast, James GD, Barnetson, Rebecca A, Penegar, Steven, Barclay, Ella, Wood, Wendy, Martin, Lynn, Gorman, Maggie, Thomas, Huw, Peto, Julian, Bishop, D Timothy, Gray, Richard, Maher, Eamonn R, Lucassen, Anneke, Kerr, David, Evans, D Gareth R, CORGI Consortium, Schafmayer, Clemens, Buch, Stephan, Völzke, Henry, Hampe, Jochen, Schreiber, Stefan, John, Ulrich, Koessler, Thibaud, Pharoah, Paul, van Wezel, Tom, Morreau, Hans, Wijnen, Juul T, Hopper, John L, Southey, Melissa C, Giles, Graham G, Severi, Gianluca, Castellví-Bel, Sergi, Ruiz-Ponte, Clara, Carracedo, Angel, Castells, Antoni, EPICOLON Consortium, Försti, Asta, Hemminki, Kari, Vodicka, Pavel, Naccarati, Alessio, Lipton, Lara, Ho, Judy WC, Cheng, KK, Sham, Pak C, Luk, J, Agúndez, Jose AG, Ladero, Jose M, de la Hoya, Miguel, Caldés, Trinidad, Niittymäki, Iina, Tuupanen, Sari, Karhu, Auli, Aaltonen, Lauri, Cazier, Jean-Baptiste, Campbell, Harry, Dunlop, Malcolm G, Houlston, Richard S |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2008 |
| المجموعة: | London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| الوصف: | To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Tomlinson, Ian PM; Webb, Emily ; Carvajal-Carmona, Luis; Broderick, Peter; Howarth, Kimberley; Pittman, Alan M; Spain, Sarah; Lubbe, Steven; Walther, Axel; Sullivan, Kate; +67 more. Jaeger, Emma; Fielding, Sarah; Rowan, Andrew; Vijayakrishnan, Jayaram; Domingo, Enric; Chandler, Ian; Kemp, Zoe; Qureshi, Mobshra; Farrington, Susan M; Tenesa, Albert; Prendergast, James GD; Barnetson, Rebecca A; Penegar, Steven; Barclay, Ella; Wood, Wendy; Martin, Lynn; Gorman, Maggie; Thomas, Huw; Peto, Julian ; Bishop, D Timothy; Gray, Richard; Maher, Eamonn R; Lucassen, Anneke; Kerr, David; Evans, D Gareth R; CORGI Consortium; Schafmayer, Clemens; Buch, Stephan; Völzke, Henry; Hampe, Jochen; Schreiber, Stefan; John, Ulrich; Koessler, Thibaud; Pharoah, Paul; van Wezel, Tom; Morreau, Hans; Wijnen, Juul T; Hopper, John L; Southey, Melissa C; Giles, Graham G; Severi, Gianluca; Castellví-Bel, Sergi; Ruiz-Ponte, Clara; Carracedo, Angel; Castells, Antoni; EPICOLON Consortium; Försti, Asta; Hemminki, Kari; Vodicka, Pavel; Naccarati, Alessio; Lipton, Lara; Ho, Judy WC; Cheng, KK; Sham, Pak C; Luk, J; Agúndez, Jose AG; Ladero, Jose M; de la Hoya, Miguel; Caldés, Trinidad; Niittymäki, Iina; Tuupanen, Sari; Karhu, Auli; Aaltonen, Lauri; Cazier, Jean-Baptiste; Campbell, Harry; Dunlop, Malcolm G; Houlston, Richard S; (2008) A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nature genetics, 40 (5). pp. 623-630. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.111Test |
| الإتاحة: | https://doi.org/10.1038/ng.111Test https://researchonline.lshtm.ac.uk/id/eprint/7584Test/ |
| رقم الانضمام: | edsbas.9EBEE69D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |