دورية أكاديمية
Population structure, biogeography and transmissibility of mycobacterium tuberculosis
| العنوان: | Population structure, biogeography and transmissibility of mycobacterium tuberculosis |
|---|---|
| المؤلفون: | Freschi, Luca, Vargas Jr., Roger, Husain, Ashaque, Kamal, S.M. Mostofa, Skrahina, Alena, Tahseen, Sabira, Ismail, Nazir Ahmed, Barbova, Anna, Niemann, Stefan, Cirillo, Daniela Maria, Dean, Anna S., Zignol, Matteo, Farhat, Maha Reda |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2021 |
| المجموعة: | University of Pretoria: UPSpace |
| مصطلحات موضوعية: | Lineages, Human, Tuberculosis (TB), Mycobacterium tuberculosis (MTB) |
| الوصف: | Mycobacterium tuberculosis is a clonal pathogen proposed to have co-evolved with its human host for millennia, yet our understanding of its genomic diversity and biogeography remains incomplete. Here we use a combination of phylogenetics and dimensionality reduction to reevaluate the population structure of M. tuberculosis, providing an in-depth analysis of the ancient Indo-Oceanic Lineage 1 and the modern Central Asian Lineage 3, and expanding our understanding of Lineages 2 and 4. We assess sub-lineages using genomic sequences from 4939 pan-susceptible strains, and find 30 new genetically distinct clades that we validate in a dataset of 4645 independent isolates. We find a consistent geographically restricted or unrestricted pattern for 20 groups, including three groups of Lineage 1. The distribution of terminal branch lengths across the M. tuberculosis phylogeny supports the hypothesis of a higher transmissibility of Lineages 2 and 4, in comparison with Lineages 3 and 1, on a global scale. We define an expanded barcode of 95 single nucleotide substitutions that allows rapid identification of 69 M. tuberculosis sub-lineages and 26 additional internal groups. Our results paint a higher resolution picture of the M. tuberculosis phylogeny and biogeography. ; http://www.nature.com/naturecommunicationsTest ; am2022 ; Medical Microbiology |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | https://repository.up.ac.za/handle/2263/88067Test; Freschi, L., Vargas Jr, R., Husain, A. et al. 2021, 'Population structure, biogeography and transmissibility of mycobacterium tuberculosis', Nature Communications, vol. 12, no. 6099, pp. 1-11, doi : 10.1038/s41467-021-26248-1. |
| DOI: | 10.1038/s41467-021-26248-1 |
| الإتاحة: | https://doi.org/10.1038/s41467-021-26248-1Test https://repository.up.ac.za/handle/2263/88067Test |
| حقوق: | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License. |
| رقم الانضمام: | edsbas.C268124D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
|---|---|
| DOI: | 10.1038/s41467-021-26248-1 |