A phantom study to contrast and compare polymer and gold fiducial markers in radiotherapy simulation imaging
| العنوان: | A phantom study to contrast and compare polymer and gold fiducial markers in radiotherapy simulation imaging |
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| المؤلفون: | Daryl Lim Joon, Drew Smith, Benjamin Harris, Mark Tacey, Wee Loon Ong, Morikatsu Wada, Trish Jenkins, Vincent Khoo, Michal Schneider, Michael Chao, Farshad Foroudi, Kym Rykers |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | Nature Publishing Group UK, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Materials science, genetic structures, medicine.medical_treatment, media_common.quotation_subject, Science, Urology, Imaging phantom, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Contrast (vision), media_common, Artifact (error), Multidisciplinary, Pixel, equipment and supplies, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, Medicine, Fiducial marker, Biomedical engineering, circulatory and respiratory physiology |
| الوصف: | To assess visibility and artifact characteristics of polymer fiducials compared to standard gold fiducials for radiotherapy CT and MRI simulation. Three gold and three polymer fiducials were inserted into a CT and MRI tissue-equivalent phantom that approximated the prostate cancer radiotherapy configuration. The phantom and fiducials were imaged on CT and MRI. Images were assessed in terms of fiducial visibility and artifact. ImageJ was employed to quantify the pixel gray-scale of each fiducial and artifact. Fiducial gray-scale histograms and profiles were generated for analysis. Objective measurements of the contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and artifact index (AI) were calculated. The CT images showed that the gold fiducials are visually brighter, with greater contrast than the polymer. The higher peak values illustrate this in the line profiles. However, they produce bright radiating and dark shadowing artifacts. This is depicted by the greater width of line profiles and the disruption of phantom area profiles. Quantitatively this results in greater percentile ranges of the histograms. Furthermore, for CT, gold had a higher CNR than polymer, relative to the phantom. However, the gold CNR and SNR were degraded by the greater artifact and thus AI. Both fiducials were visible on MRI and had similar histograms and profiles that were also reflected in comparable CNR, SNR and AI. Polymer fiducials were well visualized in a phantom on CT and MR and produce less artifact than the gold fiducials. Polymer markers could enhance the quality and accuracy of radiotherapy co-registration and planning but require clinical confirmation. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8f5979c7713244a99ed1fe17a21a1dTest http://europepmc.org/articles/PMC8076319Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c8f5979c7713244a99ed1fe17a21a1d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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