Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
| العنوان: | Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication |
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| المؤلفون: | Ditte Marie Kirkegaard-Klitbo, Andreas Knudsen, Asbjørn Fink, Børge G. Nordestgaard, Sisse R. Ostrowski, Jens D Lundgren, Rebekka Faber Thudium, Jakob Hjorth von Stemann, Shoaib Afzal, Susanne Dam Nielsen |
| المصدر: | Scientific Reports Fink, A, Knudsen, A D, Thudium, R F, Von Stemann, J H, Afzal, S, Lundgren, J, Kirkegaard-Klitbo, D M, Ostrowski, S R, Nordestgaard, B G & Nielsen, S D 2021, ' Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication ', Scientific Reports, vol. 11, no. 1, 4383 . https://doi.org/10.1038/s41598-021-83731-xTest Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021) |
| بيانات النشر: | Nature Publishing Group UK, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, medicine.drug_class, Science, HIV Infections, Logistic regression, Virus Replication, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, medicine, Humans, 030212 general & internal medicine, Blood Coagulation, Multidisciplinary, medicine.diagnostic_test, business.industry, Anticoagulant, Thrombosis, Odds ratio, Middle Aged, medicine.disease, 030112 virology, Phenotype, Blood Coagulation Factors, Coagulation, Viral replication, Medicine, Female, business, Partial thromboplastin time |
| الوصف: | Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II–VII–X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II–VII–X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c45d2957670d3da056164c04f115c32Test http://europepmc.org/articles/PMC7902813Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0c45d2957670d3da056164c04f115c32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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